2qsh

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m (Protected "2qsh" [edit=sysop:move=sysop])
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[[Image:2qsh.png|left|200px]]
 
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{{STRUCTURE_2qsh| PDB=2qsh | SCENE= }}
{{STRUCTURE_2qsh| PDB=2qsh | SCENE= }}
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===Crystal structure of Rad4-Rad23 bound to a mismatch DNA===
===Crystal structure of Rad4-Rad23 bound to a mismatch DNA===
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{{ABSTRACT_PUBMED_17882165}}
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{{ABSTRACT_PUBMED_17882165}}
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==Function==
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[[http://www.uniprot.org/uniprot/RAD23_YEAST RAD23_YEAST]] Plays a central role both in proteasomal degradation of misfolded proteins and DNA repair. Central component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes. [[http://www.uniprot.org/uniprot/RAD4_YEAST RAD4_YEAST]] Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:017882165</ref><references group="xtra"/>
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<ref group="xtra">PMID:017882165</ref><references group="xtra"/><references/>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Min, J H.]]
[[Category: Min, J H.]]

Revision as of 07:29, 30 June 2013

Template:STRUCTURE 2qsh

Contents

Crystal structure of Rad4-Rad23 bound to a mismatch DNA

Template:ABSTRACT PUBMED 17882165

Function

[RAD23_YEAST] Plays a central role both in proteasomal degradation of misfolded proteins and DNA repair. Central component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes. [RAD4_YEAST] Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.

About this Structure

2qsh is a 4 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

  • Min JH, Pavletich NP. Recognition of DNA damage by the Rad4 nucleotide excision repair protein. Nature. 2007 Oct 4;449(7162):570-5. Epub 2007 Sep 19. PMID:17882165 doi:10.1038/nature06155

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OCA

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