3qg2
From Proteopedia
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{{STRUCTURE_3qg2| PDB=3qg2 | SCENE= }} | {{STRUCTURE_3qg2| PDB=3qg2 | SCENE= }} | ||
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===Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex=== | ===Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex=== | ||
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{{ABSTRACT_PUBMED_21650210}} | {{ABSTRACT_PUBMED_21650210}} | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/D9N170_PLAFA D9N170_PLAFA]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389] | ||
==About this Structure== | ==About this Structure== | ||
[[3qg2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QG2 OCA]. | [[3qg2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QG2 OCA]. | ||
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| - | ==See Also== | ||
| - | *[[Dihydrofolate reductase|Dihydrofolate reductase]] | ||
| - | *[[Thymidylate synthase|Thymidylate synthase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021650210</ref><references group="xtra"/> | + | <ref group="xtra">PMID:021650210</ref><references group="xtra"/><references/> |
[[Category: Plasmodium falciparum]] | [[Category: Plasmodium falciparum]] | ||
[[Category: Chitnumsub, P.]] | [[Category: Chitnumsub, P.]] | ||
Revision as of 07:37, 30 June 2013
Contents |
Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex
Template:ABSTRACT PUBMED 21650210
Function
[D9N170_PLAFA] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]
About this Structure
3qg2 is a 2 chain structure with sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.
Reference
- Vanichtanankul J, Taweechai S, Yuvaniyama J, Vilaivan T, Chitnumsub P, Kamchonwongpaisan S, Yuthavong Y. Trypanosomal Dihydrofolate Reductase Reveals Natural Antifolate Resistance. ACS Chem Biol. 2011 Jun 16. PMID:21650210 doi:10.1021/cb200124r
