3u8x
From Proteopedia
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{{STRUCTURE_3u8x| PDB=3u8x | SCENE= }} | {{STRUCTURE_3u8x| PDB=3u8x | SCENE= }} | ||
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===Crystal Structure of a chimera containing the N-terminal domain (residues 8-29) of drosophila Ciboulot and the C-terminal domain (residues 18-44) of bovine Thymosin-beta4, bound to G-actin-ATP=== | ===Crystal Structure of a chimera containing the N-terminal domain (residues 8-29) of drosophila Ciboulot and the C-terminal domain (residues 18-44) of bovine Thymosin-beta4, bound to G-actin-ATP=== | ||
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{{ABSTRACT_PUBMED_22193718}} | {{ABSTRACT_PUBMED_22193718}} | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. [[http://www.uniprot.org/uniprot/TYB4_BOVIN TYB4_BOVIN]] Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase. | ||
==About this Structure== | ==About this Structure== | ||
[[3u8x]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U8X OCA]. | [[3u8x]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U8X OCA]. | ||
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| - | ==See Also== | ||
| - | *[[Actin|Actin]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:022193718</ref><references group="xtra"/> | + | <ref group="xtra">PMID:022193718</ref><references group="xtra"/><references/> |
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
Revision as of 07:42, 30 June 2013
Contents |
Crystal Structure of a chimera containing the N-terminal domain (residues 8-29) of drosophila Ciboulot and the C-terminal domain (residues 18-44) of bovine Thymosin-beta4, bound to G-actin-ATP
Template:ABSTRACT PUBMED 22193718
Function
[ACTS_RABIT] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. [TYB4_BOVIN] Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase.
About this Structure
3u8x is a 4 chain structure with sequence from Bos taurus and Oryctolagus cuniculus. Full crystallographic information is available from OCA.
Reference
- Didry D, Cantrelle FX, Husson C, Roblin P, Moorthy AM, Perez J, Le Clainche C, Hertzog M, Guittet E, Carlier MF, van Heijenoort C, Renault L. How a single residue in individual beta-thymosin/WH2 domains controls their functions in actin assembly. EMBO J. 2011 Dec 23. doi: 10.1038/emboj.2011.461. PMID:22193718 doi:10.1038/emboj.2011.461
