3b5d

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[[Image:3b5d.png|left|200px]]
 
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{{STRUCTURE_3b5d| PDB=3b5d | SCENE= }}
{{STRUCTURE_3b5d| PDB=3b5d | SCENE= }}
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===EmrE multidrug transporter in complex with TPP, C2 crystal form===
===EmrE multidrug transporter in complex with TPP, C2 crystal form===
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{{ABSTRACT_PUBMED_18024586}}
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{{ABSTRACT_PUBMED_18024586}}
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==Function==
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[[http://www.uniprot.org/uniprot/EMRE_ECOLI EMRE_ECOLI]] Multidrug transporter that expels positively charged hydrophobic drugs across the inner membrane of E.coli., thereby conferring resistance to a wide range of toxic compounds. The drug efflux is coupled to an influx of protons. Is involved in the resistance of E.coli cells to methyl viologen, ethidium bromide and acriflavine. Is also able to transport tetraphenylphosphonium (TPP(+)) and benzalkonium.<ref>PMID:7896833</ref> <ref>PMID:10681497</ref> <ref>PMID:15371426</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:018024586</ref><references group="xtra"/>
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<ref group="xtra">PMID:018024586</ref><references group="xtra"/><references/>
[[Category: Escherichia coli k-12]]
[[Category: Escherichia coli k-12]]
[[Category: Chang, G.]]
[[Category: Chang, G.]]

Revision as of 07:48, 30 June 2013

Template:STRUCTURE 3b5d

Contents

EmrE multidrug transporter in complex with TPP, C2 crystal form

Template:ABSTRACT PUBMED 18024586

Function

[EMRE_ECOLI] Multidrug transporter that expels positively charged hydrophobic drugs across the inner membrane of E.coli., thereby conferring resistance to a wide range of toxic compounds. The drug efflux is coupled to an influx of protons. Is involved in the resistance of E.coli cells to methyl viologen, ethidium bromide and acriflavine. Is also able to transport tetraphenylphosphonium (TPP(+)) and benzalkonium.[1] [2] [3]

About this Structure

3b5d is a 2 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Reference

  • Chen YJ, Pornillos O, Lieu S, Ma C, Chen AP, Chang G. X-ray structure of EmrE supports dual topology model. Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):18999-9004. Epub 2007 Nov, 16. PMID:18024586
  1. ↑ Yerushalmi H, Lebendiker M, Schuldiner S. EmrE, an Escherichia coli 12-kDa multidrug transporter, exchanges toxic cations and H+ and is soluble in organic solvents. J Biol Chem. 1995 Mar 24;270(12):6856-63. PMID:7896833
  2. ↑ Yerushalmi H, Schuldiner S. An essential glutamyl residue in EmrE, a multidrug antiporter from Escherichia coli. J Biol Chem. 2000 Feb 25;275(8):5264-9. PMID:10681497
  3. ↑ Rotem D, Schuldiner S. EmrE, a multidrug transporter from Escherichia coli, transports monovalent and divalent substrates with the same stoichiometry. J Biol Chem. 2004 Nov 19;279(47):48787-93. Epub 2004 Sep 15. PMID:15371426 doi:10.1074/jbc.M408187200

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