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4dcn

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[[Image:4dcn.jpg|left|200px]]
 
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{{STRUCTURE_4dcn| PDB=4dcn | SCENE= }}
{{STRUCTURE_4dcn| PDB=4dcn | SCENE= }}
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===Crystal Structure Analysis of the Arfaptin2 BAR domain in Complex with ARL1===
===Crystal Structure Analysis of the Arfaptin2 BAR domain in Complex with ARL1===
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{{ABSTRACT_PUBMED_22679020}}
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==Function==
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[[http://www.uniprot.org/uniprot/ARL1_HUMAN ARL1_HUMAN]] GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus.<ref>PMID:9624189</ref> [[http://www.uniprot.org/uniprot/ARFP2_HUMAN ARFP2_HUMAN]] Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling.
==About this Structure==
==About this Structure==
[[4dcn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DCN OCA].
[[4dcn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DCN OCA].
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==Reference==
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<ref group="xtra">PMID:022679020</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Kato, R.]]
[[Category: Kato, R.]]

Revision as of 07:59, 30 June 2013

Template:STRUCTURE 4dcn

Contents

Crystal Structure Analysis of the Arfaptin2 BAR domain in Complex with ARL1

Template:ABSTRACT PUBMED 22679020

Function

[ARL1_HUMAN] GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus.[1] [ARFP2_HUMAN] Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling.

About this Structure

4dcn is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Nakamura K, Man Z, Xie Y, Hanai A, Makyio H, Kawasaki M, Kato R, Shin HW, Nakayama K, Wakatsuki S. Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase. J Biol Chem. 2012 Jul 20;287(30):25478-89. doi: 10.1074/jbc.M112.365783. Epub, 2012 Jun 7. PMID:22679020 doi:10.1074/jbc.M112.365783
  1. ↑ Hong JX, Lee FJ, Patton WA, Lin CY, Moss J, Vaughan M. Phospholipid- and GTP-dependent activation of cholera toxin and phospholipase D by human ADP-ribosylation factor-like protein 1 (HARL1). J Biol Chem. 1998 Jun 19;273(25):15872-6. PMID:9624189

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