3qag
From Proteopedia
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{{STRUCTURE_3qag| PDB=3qag | SCENE= }} | {{STRUCTURE_3qag| PDB=3qag | SCENE= }} | ||
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===Human Glutathione Transferase O2 with glutathione -new crystal form=== | ===Human Glutathione Transferase O2 with glutathione -new crystal form=== | ||
| + | {{ABSTRACT_PUBMED_22522127}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/GSTO2_HUMAN GSTO2_HUMAN]] Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).<ref>PMID:15970797</ref> | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:022522127</ref><references group="xtra"/> | + | <ref group="xtra">PMID:022522127</ref><references group="xtra"/><references/> |
[[Category: Glutathione transferase]] | [[Category: Glutathione transferase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
Revision as of 08:09, 30 June 2013
Contents |
Human Glutathione Transferase O2 with glutathione -new crystal form
Template:ABSTRACT PUBMED 22522127
Function
[GSTO2_HUMAN] Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).[1]
About this Structure
3qag is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Zhou H, Brock J, Liu D, Board PG, Oakley AJ. Structural Insights into the Dehydroascorbate Reductase Activity of Human Omega-Class Glutathione Transferases. J Mol Biol. 2012 Apr 18. PMID:22522127 doi:10.1016/j.jmb.2012.04.014
- ↑ Schmuck EM, Board PG, Whitbread AK, Tetlow N, Cavanaugh JA, Blackburn AC, Masoumi A. Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases. Pharmacogenet Genomics. 2005 Jul;15(7):493-501. PMID:15970797
