1uwo
From Proteopedia
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Revision as of 14:08, 30 October 2007
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CALCIUM FORM OF HUMAN S100B, NMR, 20 STRUCTURES
Overview
BACKGROUND: S100B is a homodimeric member of the EF-hand calcium-binding, protein superfamily. The protein has been implicated in cellular processes, such as cell differentiation and growth, plays a role in cytoskeletal, structure and function, and may have a role in neuropathological diseases, such as Alzheimers. The effects of S100B are mediated via its interaction, with target proteins. While several studies have suggested that this, interaction is propagated through a calcium-induced conformational change, leading to the exposure of a hydrophobic region of S100B, the molecular, details behind this structural alteration remain unclear. RESULTS: The, solution structure of calcium-saturated human S100B (Ca(2+)-S100B) has, been determined by heteronuclear NMR spectroscopy. Ca(2+)-S100B ... [(full description)]
About this Structure
1UWO is a [Single protein] structure of sequence from [Homo sapiens]. Structure known Active Sites: CA1, CA2, CA3 and CA4. Full crystallographic information is available from [OCA].
Reference
A novel calcium-sensitive switch revealed by the structure of human S100B in the calcium-bound form., Smith SP, Shaw GS, Structure. 1998 Feb 15;6(2):211-22. PMID:9519411
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