4jbk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4jbk| PDB=4jbk | SCENE= }}
 +
===Molecular basis for abrogation of activation of pro-inflammatory cytokines===
-
The entry 4jbk is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE]] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref>
-
Authors: Ru, H., Ni, X.-M., Crowley, C., Zhao, L.-X., Ding, W., Hung, L.-W., Shaw, N., Cheng, G.-H., Liu, Z.-J.
+
==About this Structure==
 +
[[4jbk]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBK OCA].
-
Description: Molecular basis for abrogation of activation of pro-inflammatory cytokines
+
==Reference==
 +
<ref group="xtra">PMID:023567559</ref><references group="xtra"/><references/>
 +
[[Category: Mus musculus]]
 +
[[Category: Cheng, G.]]
 +
[[Category: Crowley, C.]]
 +
[[Category: Ding, W.]]
 +
[[Category: Hung, L W.]]
 +
[[Category: Liu, Z J.]]
 +
[[Category: Ni, X.]]
 +
[[Category: Ru, H.]]
 +
[[Category: Shaw, N.]]
 +
[[Category: Zhao, L.]]
 +
[[Category: Dna]]
 +
[[Category: Dna binding protein-dna complex]]
 +
[[Category: Ob fold]]

Revision as of 09:52, 30 June 2013

Template:STRUCTURE 4jbk

Contents

Molecular basis for abrogation of activation of pro-inflammatory cytokines

Function

[IFI2_MOUSE] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.[1] [2]

About this Structure

4jbk is a 8 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Ru H, Ni X, Zhao L, Crowley C, Ding W, Hung LW, Shaw N, Cheng G, Liu ZJ. Structural basis for termination of AIM2-mediated signaling by p202. Cell Res. 2013 Jun;23(6):855-8. doi: 10.1038/cr.2013.52. Epub 2013 Apr 9. PMID:23567559 doi:10.1038/cr.2013.52
  1. ↑ Xin H, D'Souza S, Jorgensen TN, Vaughan AT, Lengyel P, Kotzin BL, Choubey D. Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis. J Immunol. 2006 May 15;176(10):5863-70. PMID:16670293
  2. ↑ Roberts TL, Idris A, Dunn JA, Kelly GM, Burnton CM, Hodgson S, Hardy LL, Garceau V, Sweet MJ, Ross IL, Hume DA, Stacey KJ. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science. 2009 Feb 20;323(5917):1057-60. doi: 10.1126/science.1169841. Epub 2009, Jan 8. PMID:19131592 doi:10.1126/science.1169841

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4jbk"
Personal tools