4k45

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'''Unreleased structure'''
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{{STRUCTURE_4k45| PDB=4k45 | SCENE= }}
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===Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes===
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{{ABSTRACT_PUBMED_23777354}}
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The entry 4k45 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PLCG1_RAT PLCG1_RAT]] Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity).
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Authors: Sondek, J., Hajicek, N.
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==About this Structure==
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[[4k45]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K45 OCA].
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Description: Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes
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==Reference==
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<ref group="xtra">PMID:023777354</ref><references group="xtra"/><references/>
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[[Category: Phosphoinositide phospholipase C]]
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[[Category: Rattus norvegicus]]
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[[Category: Hajicek, N.]]
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[[Category: Sondek, J.]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Plc-gamma1]]
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[[Category: Sh2 domain]]

Revision as of 09:53, 30 June 2013

Template:STRUCTURE 4k45

Contents

Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes

Template:ABSTRACT PUBMED 23777354

Function

[PLCG1_RAT] Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity).

About this Structure

4k45 is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Hajicek N, Charpentier TH, Rush JR, Harden TK, Sondek JE. Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes. Biochemistry. 2013 Jun 18. PMID:23777354 doi:10.1021/bi400433b

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OCA

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