4aw9

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-	'''Unreleased structure'''	+	{{STRUCTURE_4aw9| PDB=4aw9 | SCENE= }}
		+	===Crystal structure of active legumain in complex with YVAD-CMK===
		+	{{ABSTRACT_PUBMED_23776206}}
-	The entry 4aw9 is ON HOLD until Paper Publication	+	==Function==
		+	[[http://www.uniprot.org/uniprot/LGMN_HUMAN LGMN_HUMAN]] Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
-	Authors: Dall, E., Brandstetter, H.	+	==About this Structure==
		+	[[4aw9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AW9 OCA].
-	Description: Crystal structure of active legumain in complex with YVAD-CMK	+	==Reference==
		+	<ref group="xtra">PMID:023776206</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Legumain]]
		+	[[Category: Brandstetter, H.]]
		+	[[Category: Dall, E.]]
		+	[[Category: Aep]]
		+	[[Category: Antigen processing]]
		+	[[Category: Cancer]]
		+	[[Category: Cysteine protease]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Lysosomal]]
		+	[[Category: Mhcii]]
		+	[[Category: Substrate specificity]]

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Revision as of 10:04, 30 June 2013

Template:STRUCTURE 4aw9

Contents 1 Crystal structure of active legumain in complex with YVAD-CMK 2 Function 3 About this Structure 4 Reference

Crystal structure of active legumain in complex with YVAD-CMK

Template:ABSTRACT PUBMED 23776206

Function

[LGMN_HUMAN] Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.

About this Structure

4aw9 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Dall E, Brandstetter H. Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation. Proc Natl Acad Sci U S A. 2013 Jun 17. PMID:23776206 doi:10.1073/pnas.1300686110