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3vtq

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_3vtq| PDB=3vtq | SCENE= }}
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===Novel HIV fusion inhibitor===
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The entry 3vtq is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/Q9YP39_9HIV1 Q9YP39_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).
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Authors: Yao, X., Waltersperger, S., Wang, M., Cui, S.
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==About this Structure==
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[[3vtq]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VTQ OCA].
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Description: Novel HIV fusion inhibitor
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[[Category: Cui, S.]]
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[[Category: Waltersperger, S.]]
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[[Category: Wang, M.]]
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[[Category: Yao, X.]]
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[[Category: 6-helix bundle]]
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[[Category: Coiled-coil]]
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[[Category: Fusion inhibitor]]
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[[Category: M-t hook]]
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[[Category: Membrane]]
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[[Category: Viral protein-antiviral protein complex]]

Revision as of 10:18, 30 June 2013

Template:STRUCTURE 3vtq

Novel HIV fusion inhibitor

Function

[Q9YP39_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).

About this Structure

3vtq is a 6 chain structure. Full crystallographic information is available from OCA.

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OCA

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