3sbk

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[[Image:3sbk.jpg|left|200px]]
 
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{{STRUCTURE_3sbk| PDB=3sbk | SCENE= }}
{{STRUCTURE_3sbk| PDB=3sbk | SCENE= }}
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===Russell's viper venom serine proteinase, RVV-V (PPACK-bound form)===
===Russell's viper venom serine proteinase, RVV-V (PPACK-bound form)===
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{{ABSTRACT_PUBMED_21871889}}
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==Function==
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[[http://www.uniprot.org/uniprot/VSPG_DABSI VSPG_DABSI]] Venom serine protease that selectively activates factor V (F5) in a calcium-independent manner. It cleaves the Arg(1545)-Ser(1546) linkage in the human factor V molecule. Induces the coagulation of mammalian plasma.<ref>PMID:3053712</ref>
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{{ABSTRACT_PUBMED_21871889}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:021871889</ref><ref group="xtra">PMID:020054136</ref><references group="xtra"/>
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<ref group="xtra">PMID:021871889</ref><references group="xtra"/><references/>
[[Category: Daboia russellii siamensis]]
[[Category: Daboia russellii siamensis]]
[[Category: Snake venom factor V activator]]
[[Category: Snake venom factor V activator]]

Revision as of 07:09, 3 July 2013

Template:STRUCTURE 3sbk

Contents

Russell's viper venom serine proteinase, RVV-V (PPACK-bound form)

Template:ABSTRACT PUBMED 21871889

Function

[VSPG_DABSI] Venom serine protease that selectively activates factor V (F5) in a calcium-independent manner. It cleaves the Arg(1545)-Ser(1546) linkage in the human factor V molecule. Induces the coagulation of mammalian plasma.[1]

About this Structure

3sbk is a 1 chain structure with sequence from Daboia russellii siamensis. Full crystallographic information is available from OCA.

Reference

  • Nakayama D, Ben Ammar Y, Miyata T, Takeda S. Structural basis of coagulation factor V recognition for cleavage by RVV-V. FEBS Lett. 2011 Aug 23. PMID:21871889 doi:10.1016/j.febslet.2011.08.022
  1. ↑ Tokunaga F, Nagasawa K, Tamura S, Miyata T, Iwanaga S, Kisiel W. The factor V-activating enzyme (RVV-V) from Russell's viper venom. Identification of isoproteins RVV-V alpha, -V beta, and -V gamma and their complete amino acid sequences. J Biol Chem. 1988 Nov 25;263(33):17471-81. PMID:3053712

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