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3v46
From Proteopedia
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{{STRUCTURE_3v46| PDB=3v46 | SCENE= }} | {{STRUCTURE_3v46| PDB=3v46 | SCENE= }} | ||
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===Crystal Structure of Yeast Cdc73 C-Terminal Domain=== | ===Crystal Structure of Yeast Cdc73 C-Terminal Domain=== | ||
| + | {{ABSTRACT_PUBMED_22318720}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/CDC73_YEAST CDC73_YEAST]] The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B. Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2.<ref>PMID:9032243</ref> <ref>PMID:15643076</ref> <ref>PMID:16246725</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3v46]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3v46]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V46 OCA]. |
| - | [[Category: Saccharomyces cerevisiae]] | + | |
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:022318720</ref><references group="xtra"/><references/> | ||
| + | [[Category: Saccharomyces cerevisiae s288c]] | ||
[[Category: Amrich, C G.]] | [[Category: Amrich, C G.]] | ||
[[Category: VanDemark, A P.]] | [[Category: VanDemark, A P.]] | ||
Revision as of 09:35, 3 July 2013
Contents |
Crystal Structure of Yeast Cdc73 C-Terminal Domain
Template:ABSTRACT PUBMED 22318720
Function
[CDC73_YEAST] The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B. Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2.[1] [2] [3]
About this Structure
3v46 is a 1 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.
Reference
- Amrich CG, Davis CP, Rogal WP, Shirra MK, Heroux A, Gardner RG, Arndt KM, VanDemark AP. Cdc73 subunit of Paf1 complex contains C-terminal Ras-like domain that promotes association of Paf1 complex with chromatin. J Biol Chem. 2012 Mar 30;287(14):10863-75. Epub 2012 Feb 8. PMID:22318720 doi:10.1074/jbc.M111.325647
- ↑ Shi X, Chang M, Wolf AJ, Chang CH, Frazer-Abel AA, Wade PA, Burton ZF, Jaehning JA. Cdc73p and Paf1p are found in a novel RNA polymerase II-containing complex distinct from the Srbp-containing holoenzyme. Mol Cell Biol. 1997 Mar;17(3):1160-9. PMID:9032243
- ↑ Porter SE, Penheiter KL, Jaehning JA. Separation of the Saccharomyces cerevisiae Paf1 complex from RNA polymerase II results in changes in its subnuclear localization. Eukaryot Cell. 2005 Jan;4(1):209-20. PMID:15643076 doi:http://dx.doi.org/10.1128/EC.4.1.209-220.2005
- ↑ Sheldon KE, Mauger DM, Arndt KM. A Requirement for the Saccharomyces cerevisiae Paf1 complex in snoRNA 3' end formation. Mol Cell. 2005 Oct 28;20(2):225-36. PMID:16246725 doi:S1097-2765(05)01568-6
