4da1
From Proteopedia
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{{STRUCTURE_4da1| PDB=4da1 | SCENE= }} | {{STRUCTURE_4da1| PDB=4da1 | SCENE= }} | ||
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===Crystal structure of branched-chain alpha-ketoacid dehydrogenase phosphatase with Mg (II) ions at the active site=== | ===Crystal structure of branched-chain alpha-ketoacid dehydrogenase phosphatase with Mg (II) ions at the active site=== | ||
| + | {{ABSTRACT_PUBMED_22291014}} | ||
| + | ==Disease== | ||
| + | [[http://www.uniprot.org/uniprot/PPM1K_HUMAN PPM1K_HUMAN]] Intermediate maple syrup urine disease. | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/PPM1K_HUMAN PPM1K_HUMAN]] Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.<ref>PMID:17374715</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[4da1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DA1 OCA]. | [[4da1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DA1 OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:022291014</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Phosphoprotein phosphatase]] | [[Category: Phosphoprotein phosphatase]] | ||
Revision as of 09:44, 3 July 2013
Contents |
Crystal structure of branched-chain alpha-ketoacid dehydrogenase phosphatase with Mg (II) ions at the active site
Template:ABSTRACT PUBMED 22291014
Disease
[PPM1K_HUMAN] Intermediate maple syrup urine disease.
Function
[PPM1K_HUMAN] Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.[1]
About this Structure
4da1 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Wynn RM, Li J, Brautigam CA, Chuang JL, Chuang DT. Structural and biochemical characterization of human mitochondrial branched-chain alpha-ketoacid dehydrogenase phosphatase. J Biol Chem. 2012 Mar 16;287(12):9178-92. Epub 2012 Jan 30. PMID:22291014 doi:10.1074/jbc.M111.314963
- ↑ Lu G, Ren S, Korge P, Choi J, Dong Y, Weiss J, Koehler C, Chen JN, Wang Y. A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development. Genes Dev. 2007 Apr 1;21(7):784-96. Epub 2007 Mar 20. PMID:17374715 doi:http://dx.doi.org/10.1101/gad.1499107
