3g75

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:3g75.png|left|200px]]
 
- 
{{STRUCTURE_3g75| PDB=3g75 | SCENE= }}
{{STRUCTURE_3g75| PDB=3g75 | SCENE= }}
 +
===Crystal structure of Staphylococcus aureus Gyrase B co-complexed with 4-METHYL-5-[3-(METHYLSULFANYL)-1H-PYRAZOL-5-YL]-2-THIOPHEN-2-YL-1,3-THIAZOLE inhibitor===
 +
{{ABSTRACT_PUBMED_20356737}}
-
===Crystal structure of Staphylococcus aureus Gyrase B co-complexed with inhibitor===
+
==Function==
-
 
+
[[http://www.uniprot.org/uniprot/GYRB_STAAU GYRB_STAAU]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01898]
==About this Structure==
==About this Structure==
[[3g75]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G75 OCA].
[[3g75]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G75 OCA].
-
==See Also==
+
==Reference==
-
*[[Gyrase|Gyrase]]
+
<ref group="xtra">PMID:020356737</ref><references group="xtra"/><references/>
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Charifson, P.]]
[[Category: Charifson, P.]]
Line 16: Line 16:
[[Category: Antibiotic resistance]]
[[Category: Antibiotic resistance]]
[[Category: Isomerase]]
[[Category: Isomerase]]
 +
[[Category: Isomerase-isomerase inhibitor complex]]

Revision as of 10:15, 3 July 2013

Template:STRUCTURE 3g75

Contents

Crystal structure of Staphylococcus aureus Gyrase B co-complexed with 4-METHYL-5-[3-(METHYLSULFANYL)-1H-PYRAZOL-5-YL]-2-THIOPHEN-2-YL-1,3-THIAZOLE inhibitor

Template:ABSTRACT PUBMED 20356737

Function

[GYRB_STAAU] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01898]

About this Structure

3g75 is a 2 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

  • Ronkin SM, Badia M, Bellon S, Grillot AL, Gross CH, Grossman TH, Mani N, Parsons JD, Stamos D, Trudeau M, Wei Y, Charifson PS. Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase. Bioorg Med Chem Lett. 2010 May 1;20(9):2828-31. doi: 10.1016/j.bmcl.2010.03.052. , Epub 2010 Mar 15. PMID:20356737 doi:10.1016/j.bmcl.2010.03.052

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3g75"
Personal tools