2i1p
From Proteopedia
(New page: 200px<br /><applet load="2i1p" size="450" color="white" frame="true" align="right" spinBox="true" caption="2i1p" /> '''Solution structure of the twelfth cysteine-r...) |
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'''Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin'''<br /> | '''Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Megalin, an approx. 600 kDa transmembrane glycoprotein that acts as | + | Megalin, an approx. 600 kDa transmembrane glycoprotein that acts as multi-ligand transporter, is a member of the low density lipoprotein receptor gene family. Several cysteine-rich repeats, each consisting of about 40 residues, are responsible for the multispecific binding of ligands. The solution structure of the twelfth cysteine-rich ligand-binding repeat with class A motif found in megalin features two short beta-strands and two helical turns, yielding the typical fold with a I-III, II-V and IV-VI disulfide bridge connectivity pattern and a calcium coordination site at the C-terminal end. The resulting differences in electrostatic surface potential compared to other ligand-binding modules of this gene family, however, may be responsible for the functional divergence. |
==About this Structure== | ==About this Structure== | ||
| - | 2I1P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2I1P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Rueterjans, H.]] | [[Category: Rueterjans, H.]] | ||
[[Category: Shi, M.]] | [[Category: Shi, M.]] | ||
| - | [[Category: Wolf, C | + | [[Category: Wolf, C A.]] |
[[Category: CA]] | [[Category: CA]] | ||
[[Category: calcium cage]] | [[Category: calcium cage]] | ||
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[[Category: low density lipoprotein receptor]] | [[Category: low density lipoprotein receptor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:48:07 2008'' |
Revision as of 15:48, 21 February 2008
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Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin
Overview
Megalin, an approx. 600 kDa transmembrane glycoprotein that acts as multi-ligand transporter, is a member of the low density lipoprotein receptor gene family. Several cysteine-rich repeats, each consisting of about 40 residues, are responsible for the multispecific binding of ligands. The solution structure of the twelfth cysteine-rich ligand-binding repeat with class A motif found in megalin features two short beta-strands and two helical turns, yielding the typical fold with a I-III, II-V and IV-VI disulfide bridge connectivity pattern and a calcium coordination site at the C-terminal end. The resulting differences in electrostatic surface potential compared to other ligand-binding modules of this gene family, however, may be responsible for the functional divergence.
About this Structure
2I1P is a Single protein structure of sequence from Rattus norvegicus with as ligand. Full crystallographic information is available from OCA.
Reference
Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin., Wolf CA, Dancea F, Shi M, Bade-Noskova V, Ruterjans H, Kerjaschki D, Lucke C, J Biomol NMR. 2007 Apr;37(4):321-8. Epub 2007 Jan 24. PMID:17245526
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