3g7b
From Proteopedia
(Difference between revisions)
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| - | [[Image:3g7b.png|left|200px]] | ||
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{{STRUCTURE_3g7b| PDB=3g7b | SCENE= }} | {{STRUCTURE_3g7b| PDB=3g7b | SCENE= }} | ||
| + | ===Staphylococcus aureus Gyrase B co-complex with METHYL ({5-[4-(4-HYDROXYPIPERIDIN-1-YL)-2-PHENYL-1,3-THIAZOL-5-YL]-1H-PYRAZOL-3-YL}METHYL)CARBAMATE inhibitor=== | ||
| + | {{ABSTRACT_PUBMED_20356737}} | ||
| - | == | + | ==Function== |
| - | + | [[http://www.uniprot.org/uniprot/GYRB_STAAU GYRB_STAAU]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01898] | |
==About this Structure== | ==About this Structure== | ||
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==See Also== | ==See Also== | ||
*[[Gyrase|Gyrase]] | *[[Gyrase|Gyrase]] | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:020356737</ref><references group="xtra"/><references/> | ||
[[Category: Staphylococcus aureus]] | [[Category: Staphylococcus aureus]] | ||
[[Category: Charisfon, P.]] | [[Category: Charisfon, P.]] | ||
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[[Category: Antibiotic resistance]] | [[Category: Antibiotic resistance]] | ||
[[Category: Isomerase]] | [[Category: Isomerase]] | ||
| + | [[Category: Isomerase-isomerase inhibitor complex]] | ||
Revision as of 11:37, 3 July 2013
Contents |
Staphylococcus aureus Gyrase B co-complex with METHYL ({5-[4-(4-HYDROXYPIPERIDIN-1-YL)-2-PHENYL-1,3-THIAZOL-5-YL]-1H-PYRAZOL-3-YL}METHYL)CARBAMATE inhibitor
Template:ABSTRACT PUBMED 20356737
Function
[GYRB_STAAU] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01898]
About this Structure
3g7b is a 2 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.
See Also
Reference
- Ronkin SM, Badia M, Bellon S, Grillot AL, Gross CH, Grossman TH, Mani N, Parsons JD, Stamos D, Trudeau M, Wei Y, Charifson PS. Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase. Bioorg Med Chem Lett. 2010 May 1;20(9):2828-31. doi: 10.1016/j.bmcl.2010.03.052. , Epub 2010 Mar 15. PMID:20356737 doi:10.1016/j.bmcl.2010.03.052
