3spd
From Proteopedia
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{{STRUCTURE_3spd| PDB=3spd | SCENE= }} | {{STRUCTURE_3spd| PDB=3spd | SCENE= }} | ||
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===Crystal structure of aprataxin ortholog Hnt3 in complex with DNA=== | ===Crystal structure of aprataxin ortholog Hnt3 in complex with DNA=== | ||
| + | {{ABSTRACT_PUBMED_21984208}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/APTX_SCHPO APTX_SCHPO]] DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity). | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3spd]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3spd]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SPD OCA]. |
| - | [[Category: Schizosaccharomyces pombe]] | + | |
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:021984208</ref><references group="xtra"/><references/> | ||
| + | [[Category: Schizosaccharomyces pombe 972h-]] | ||
[[Category: Ding, J.]] | [[Category: Ding, J.]] | ||
[[Category: Dou, C.]] | [[Category: Dou, C.]] | ||
Revision as of 12:01, 3 July 2013
Contents |
Crystal structure of aprataxin ortholog Hnt3 in complex with DNA
Template:ABSTRACT PUBMED 21984208
Function
[APTX_SCHPO] DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity).
About this Structure
3spd is a 8 chain structure with sequence from Schizosaccharomyces pombe 972h-. Full crystallographic information is available from OCA.
Reference
- Gong Y, Zhu D, Ding J, Dou CN, Ren X, Gu L, Jiang T, Wang DC. Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA. Nat Struct Mol Biol. 2011 Oct 9;18(11):1297-9. doi: 10.1038/nsmb.2145. PMID:21984208 doi:10.1038/nsmb.2145
