3rzi

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[[Image:3rzi.png|left|200px]]
 
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{{STRUCTURE_3rzi| PDB=3rzi | SCENE= }}
{{STRUCTURE_3rzi| PDB=3rzi | SCENE= }}
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===The structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from mycobacterium tuberculosis cocrystallized and complexed with phenylalanine and tryptophan===
===The structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from mycobacterium tuberculosis cocrystallized and complexed with phenylalanine and tryptophan===
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{{ABSTRACT_PUBMED_22154807}}
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==Function==
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[[http://www.uniprot.org/uniprot/AROG_MYCTU AROG_MYCTU]] Catalyzes an aldol-like condensation reaction between phosphoenolpyruvate (PEP) and D-erythrose 4-phosphate (E4P) to generate 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAH7P) and inorganic phosphate.<ref>PMID:16288916</ref>
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{{ABSTRACT_PUBMED_22154807}}
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==About this Structure==
==About this Structure==
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[[3rzi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RZI OCA].
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[[3rzi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RZI OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:022154807</ref><references group="xtra"/>
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<ref group="xtra">PMID:022154807</ref><references group="xtra"/><references/>
[[Category: 3-deoxy-7-phosphoheptulonate synthase]]
[[Category: 3-deoxy-7-phosphoheptulonate synthase]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Mycobacterium tuberculosis h37rv]]
[[Category: Hutton, R D.]]
[[Category: Hutton, R D.]]
[[Category: Jameson, G B.]]
[[Category: Jameson, G B.]]

Revision as of 12:08, 3 July 2013

Template:STRUCTURE 3rzi

Contents

The structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from mycobacterium tuberculosis cocrystallized and complexed with phenylalanine and tryptophan

Template:ABSTRACT PUBMED 22154807

Function

[AROG_MYCTU] Catalyzes an aldol-like condensation reaction between phosphoenolpyruvate (PEP) and D-erythrose 4-phosphate (E4P) to generate 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAH7P) and inorganic phosphate.[1]

About this Structure

3rzi is a 2 chain structure with sequence from Mycobacterium tuberculosis h37rv. Full crystallographic information is available from OCA.

Reference

  • Jiao W, Hutton RD, Cross PJ, Jameson GB, Parker EJ. Dynamic Cross-Talk among Remote Binding Sites: The Molecular Basis for Unusual Synergistic Allostery. J Mol Biol. 2012 Jan 27;415(4):716-26. Epub 2011 Dec 2. PMID:22154807 doi:10.1016/j.jmb.2011.11.037
  1. ↑ Webby CJ, Baker HM, Lott JS, Baker EN, Parker EJ. The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes. J Mol Biol. 2005 Dec 9;354(4):927-39. Epub 2005 Oct 21. PMID:16288916 doi:10.1016/j.jmb.2005.09.093

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