4es4
From Proteopedia
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{{STRUCTURE_4es4| PDB=4es4 | SCENE= }} | {{STRUCTURE_4es4| PDB=4es4 | SCENE= }} | ||
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===Crystal structure of YdiV and FlhD complex=== | ===Crystal structure of YdiV and FlhD complex=== | ||
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{{ABSTRACT_PUBMED_23002140}} | {{ABSTRACT_PUBMED_23002140}} | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/YDIV_ECOLI YDIV_ECOLI]] Upon overexpression acts as a novel anti-FlhC(2)FlhD(4) factor, decreasing its DNA-binding activity, able to negatively regulate expression of flagellar class II operons including FliC.<ref>PMID:22461489</ref> [[http://www.uniprot.org/uniprot/FLHD_ECOLI FLHD_ECOLI]] Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.<ref>PMID:7961507</ref> <ref>PMID:11169100</ref> <ref>PMID:15941987</ref> <ref>PMID:18765794</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | [[4es4]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ES4 OCA]. | + | [[4es4]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ES4 OCA]. |
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023002140</ref><references group="xtra"/><references/> | ||
| + | [[Category: Escherichia coli k-12]] | ||
[[Category: Gu, L.]] | [[Category: Gu, L.]] | ||
[[Category: Li, B.]] | [[Category: Li, B.]] | ||
[[Category: Flagellar regulation]] | [[Category: Flagellar regulation]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
Revision as of 12:20, 3 July 2013
Contents |
Crystal structure of YdiV and FlhD complex
Template:ABSTRACT PUBMED 23002140
Function
[YDIV_ECOLI] Upon overexpression acts as a novel anti-FlhC(2)FlhD(4) factor, decreasing its DNA-binding activity, able to negatively regulate expression of flagellar class II operons including FliC.[1] [FLHD_ECOLI] Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.[2] [3] [4] [5]
About this Structure
4es4 is a 8 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.
Reference
- Li B, Li N, Wang F, Guo L, Huang Y, Liu X, Wei T, Zhu D, Liu C, Pan H, Xu S, Wang HW, Gu L. Structural insight of a concentration-dependent mechanism by which YdiV inhibits Escherichia coli flagellum biogenesis and motility. Nucleic Acids Res. 2012 Sep 21. PMID:23002140 doi:10.1093/nar/gks869
- ↑ Wada T, Hatamoto Y, Kutsukake K. Functional and expressional analyses of the anti-FlhD4C2 factor gene ydiV in Escherichia coli. Microbiology. 2012 Jun;158(Pt 6):1533-42. doi: 10.1099/mic.0.056036-0. Epub 2012 , Mar 29. PMID:22461489 doi:http://dx.doi.org/10.1099/mic.0.056036-0
- ↑ Liu X, Matsumura P. The FlhD/FlhC complex, a transcriptional activator of the Escherichia coli flagellar class II operons. J Bacteriol. 1994 Dec;176(23):7345-51. PMID:7961507
- ↑ Campos A, Matsumura P. Extensive alanine scanning reveals protein-protein and protein-DNA interaction surfaces in the global regulator FlhD from Escherichia coli. Mol Microbiol. 2001 Feb;39(3):581-94. PMID:11169100
- ↑ Stafford GP, Ogi T, Hughes C. Binding and transcriptional activation of non-flagellar genes by the Escherichia coli flagellar master regulator FlhD2C2. Microbiology. 2005 Jun;151(Pt 6):1779-88. PMID:15941987 doi:10.1099/mic.0.27879-0
- ↑ Pesavento C, Becker G, Sommerfeldt N, Possling A, Tschowri N, Mehlis A, Hengge R. Inverse regulatory coordination of motility and curli-mediated adhesion in Escherichia coli. Genes Dev. 2008 Sep 1;22(17):2434-46. doi: 10.1101/gad.475808. PMID:18765794 doi:10.1101/gad.475808
