3syv
From Proteopedia
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{{STRUCTURE_3syv| PDB=3syv | SCENE= }} | {{STRUCTURE_3syv| PDB=3syv | SCENE= }} | ||
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===Crystal structure of mPACSIN 3 F-BAR domain mutant=== | ===Crystal structure of mPACSIN 3 F-BAR domain mutant=== | ||
| + | {{ABSTRACT_PUBMED_22573331}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/PACN3_MOUSE PACN3_MOUSE]] Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity. | ||
==About this Structure== | ==About this Structure== | ||
[[3syv]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SYV OCA]. | [[3syv]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SYV OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:022573331</ref><references group="xtra"/><references/> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Bai, X.]] | [[Category: Bai, X.]] | ||
Revision as of 12:36, 3 July 2013
Contents |
Crystal structure of mPACSIN 3 F-BAR domain mutant
Template:ABSTRACT PUBMED 22573331
Function
[PACN3_MOUSE] Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.
About this Structure
3syv is a 8 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Bai X, Meng G, Luo M, Zheng X. The rigidity of the wedge loop in PACSIN 3 is a key factor in dictating the diameters of tubules. J Biol Chem. 2012 May 9. PMID:22573331 doi:10.1074/jbc.M112.358960
