4gum

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'''Unreleased structure'''
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{{STRUCTURE_4gum| PDB=4gum | SCENE= }}
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===Cystal structure of locked-trimer of human MIF===
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{{ABSTRACT_PUBMED_23776208}}
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The entry 4gum is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/MIF_MACMU MIF_MACMU]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By similarity).
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Authors: Fan, C., Lolis, E.
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==About this Structure==
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[[4gum]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GUM OCA].
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Description: Cystal structure of locked-trimer of human MIF
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==Reference==
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<ref group="xtra">PMID:023776208</ref><references group="xtra"/><references/>
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[[Category: Macaca mulatta]]
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[[Category: Fan, C.]]
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[[Category: Lolis, E.]]
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[[Category: Alpha/beta mixture]]
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[[Category: Cytokine and isomerase]]
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[[Category: Isomerase]]

Revision as of 14:04, 3 July 2013

Template:STRUCTURE 4gum

Contents

Cystal structure of locked-trimer of human MIF

Template:ABSTRACT PUBMED 23776208

Function

[MIF_MACMU] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By similarity).

About this Structure

4gum is a 9 chain structure with sequence from Macaca mulatta. Full crystallographic information is available from OCA.

Reference

  • Fan C, Rajasekaran D, Syed MA, Leng L, Loria JP, Bhandari V, Bucala R, Lolis EJ. MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations. Proc Natl Acad Sci U S A. 2013 Jun 17. PMID:23776208 doi:10.1073/pnas.1221817110

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