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4h54

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'''Unreleased structure'''
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{{STRUCTURE_4h54| PDB=4h54 | SCENE= }}
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===Crystal structure of the diguanylate cyclase DgcZ===
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{{ABSTRACT_PUBMED_23769666}}
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The entry 4h54 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/YDEH_ECOLI YDEH_ECOLI]] A diguanylate cyclase, overexpression leads to a strong repression of swimming; swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di-GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria.<ref>PMID:19460094</ref>
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Authors: Zaehringer, F., Schirmer, T.
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==About this Structure==
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[[4h54]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H54 OCA].
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Description: Crystal structure of the diguanylate cyclase DgcZ
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==Reference==
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<ref group="xtra">PMID:023769666</ref><references group="xtra"/><references/>
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[[Category: Diguanylate cyclase]]
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[[Category: Escherichia coli k-12]]
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[[Category: Schirmer, T.]]
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[[Category: Zaehringer, F.]]
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[[Category: C-di-gmp]]
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[[Category: Czb domain]]
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[[Category: Transferase]]
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[[Category: Zinc sensor]]

Revision as of 14:04, 3 July 2013

Template:STRUCTURE 4h54

Contents

Crystal structure of the diguanylate cyclase DgcZ

Template:ABSTRACT PUBMED 23769666

Function

[YDEH_ECOLI] A diguanylate cyclase, overexpression leads to a strong repression of swimming; swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di-GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria.[1]

About this Structure

4h54 is a 2 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Reference

  • Zahringer F, Lacanna E, Jenal U, Schirmer T, Boehm A. Structure and Signaling Mechanism of a Zinc-Sensory Diguanylate Cyclase. Structure. 2013 Jun 11. pii: S0969-2126(13)00156-1. doi:, 10.1016/j.str.2013.04.026. PMID:23769666 doi:10.1016/j.str.2013.04.026
  1. ↑ Boehm A, Steiner S, Zaehringer F, Casanova A, Hamburger F, Ritz D, Keck W, Ackermann M, Schirmer T, Jenal U. Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress. Mol Microbiol. 2009 Jun;72(6):1500-16. doi: 10.1111/j.1365-2958.2009.06739.x., Epub 2009 May 15. PMID:19460094 doi:10.1111/j.1365-2958.2009.06739.x

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