4bm7

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m (Protected "4bm7" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4bm7| PDB=4bm7 | SCENE= }}
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===Crystal Structure of IgG Fc F241A mutant with native glycosylation===
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{{ABSTRACT_PUBMED_23745692}}
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The entry 4bm7 is ON HOLD
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==Disease==
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[[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
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Authors: Yu, X., Baruah, K., Harvey, D.J., Vasiljevic, S., Alonzi, D.S., Song, B., Higgins, M.K., Bowden, T.A., Crispin, M., Scanlan, C.N.
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==About this Structure==
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[[4bm7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BM7 OCA].
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Description: Crystal Structure of IgG Fc F241A mutant with native glycosylation
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==Reference==
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<ref group="xtra">PMID:023745692</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Alonzi, D S.]]
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[[Category: Baruah, K.]]
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[[Category: Bowden, T A.]]
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[[Category: Crispin, M.]]
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[[Category: Harvey, D J.]]
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[[Category: Higgins, M K.]]
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[[Category: Scanlan, C N.]]
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[[Category: Song, B.]]
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[[Category: Vasiljevic, S.]]
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[[Category: Yu, X.]]
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[[Category: Glycan]]
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[[Category: Immune system]]

Revision as of 14:07, 3 July 2013

Template:STRUCTURE 4bm7

Contents

Crystal Structure of IgG Fc F241A mutant with native glycosylation

Template:ABSTRACT PUBMED 23745692

Disease

[IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.

About this Structure

4bm7 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Yu X, Baruah K, Harvey DJ, Vasiljevic S, Alonzi DS, Song BD, Higgins MK, Bowden TA, Scanlan CN, Crispin M. Engineering hydrophobic protein-carbohydrate interactions to fine-tune monoclonal antibodies. J Am Chem Soc. 2013 Jun 7. PMID:23745692 doi:10.1021/ja4014375

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OCA

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