4k7q

(Difference between revisions)

Revision as of 14:07, 3 July 2013

[ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.^[1] ^[2] ^[3]

4k7q is a 1 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Hung LW, Kim HB, Murakami S, Gupta G, Kim CY, Terwilliger TC. Crystal structure of AcrB complexed with linezolid at 3.5 A resolution. J Struct Funct Genomics. 2013 Jun;14(2):71-5. doi: 10.1007/s10969-013-9154-x., Epub 2013 May 15. PMID:23673416 doi:10.1007/s10969-013-9154-x

↑ Murakami S, Nakashima R, Yamashita E, Matsumoto T, Yamaguchi A. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature. 2006 Sep 14;443(7108):173-9. Epub 2006 Aug 16. PMID:16915237 doi:10.1038/nature05076
↑ Seeger MA, Schiefner A, Eicher T, Verrey F, Diederichs K, Pos KM. Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism. Science. 2006 Sep 1;313(5791):1295-8. PMID:16946072 doi:313/5791/1295
↑ Sennhauser G, Amstutz P, Briand C, Storchenegger O, Grutter MG. Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. PLoS Biol. 2007 Jan;5(1):e7. PMID:17194213 doi:10.1371/journal.pbio.0050007

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-'''Unreleased structure'''
+{{STRUCTURE_4k7q|  PDB=4k7q  |  SCENE=  }}
+===Crystal Structure of AcrB Complexed with Linezolid at 3.5 Resolution===
+{{ABSTRACT_PUBMED_23673416}}
-The entry 4k7q is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI]] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>
-Authors: Hung, L.W., Kim, H.B., Murakami, S., Gupta, G., Kim, C.Y., Terwilliger, T.C.
+==About this Structure==
+[[4k7q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K7Q OCA].
-Description: Crystal Structure of AcrB Complexed with Linezolid at 3.5 Resolution
+==Reference==
+<ref group="xtra">PMID:023673416</ref><references group="xtra"/><references/>
+[[Category: Escherichia coli k-12]]
+[[Category: Gupta, G.]]
+[[Category: Hung, L W.]]
+[[Category: Kim, C Y.]]
+[[Category: Kim, H B.]]
+[[Category: Murakami, S.]]
+[[Category: Terwilliger, T C.]]
+[[Category: Inner membrane resistance-nodulation-cell division efflux pump]]
+[[Category: Membrane protein-antibiotic complex]]