3w15

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'''Unreleased structure'''
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{{STRUCTURE_3w15| PDB=3w15 | SCENE= }}
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===Structure of peroxisomal targeting signal 2 (PTS2) of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase in complex with Pex7p and Pex21p===
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The entry 3w15 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PEX7_YEAST PEX7_YEAST]] Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import essential for import of 3-oxoacyl-CoA thiolase (a PTS2-containing protein) into peroxisomes. May direct thiolase to peroxisomes by shuttling between the cytosol and peroxisomal membranes. [[http://www.uniprot.org/uniprot/PEX21_YEAST PEX21_YEAST]] Involved in peroxisome biogenesis and the import of peroxisomal matrix proteins that contain the peroxisomal targeting sequence PTS2. Required for peroxisomal targeting of PEX7 and growth on oleate. Acts as an activator of the seryl-tRNA synthetase SES1 by increasing its binding to tRNA.<ref>PMID:9864360</ref> <ref>PMID:12204379</ref> <ref>PMID:12167700</ref> <ref>PMID:17451428</ref>
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Authors: Pan, D., Nakatsu, T., Kato, H.
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==About this Structure==
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[[3w15]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W15 OCA].
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Description: A peroxin complex
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Saccharomyces cerevisiae s288c]]
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[[Category: Kato, H.]]
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[[Category: Nakatsu, T.]]
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[[Category: Pan, D.]]
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[[Category: Beta-propeller]]
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[[Category: Cytosol]]
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[[Category: Peroxisome]]
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[[Category: Protein transport]]
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[[Category: Targeting signal recognition]]

Revision as of 14:12, 3 July 2013

Template:STRUCTURE 3w15

Contents

Structure of peroxisomal targeting signal 2 (PTS2) of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase in complex with Pex7p and Pex21p

Function

[PEX7_YEAST] Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import essential for import of 3-oxoacyl-CoA thiolase (a PTS2-containing protein) into peroxisomes. May direct thiolase to peroxisomes by shuttling between the cytosol and peroxisomal membranes. [PEX21_YEAST] Involved in peroxisome biogenesis and the import of peroxisomal matrix proteins that contain the peroxisomal targeting sequence PTS2. Required for peroxisomal targeting of PEX7 and growth on oleate. Acts as an activator of the seryl-tRNA synthetase SES1 by increasing its binding to tRNA.[1] [2] [3] [4]

About this Structure

3w15 is a 3 chain structure with sequence from [1] and Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.

Reference

  1. ↑ Purdue PE, Yang X, Lazarow PB. Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway. J Cell Biol. 1998 Dec 28;143(7):1859-69. PMID:9864360
  2. ↑ Rocak S, Landeka I, Weygand-Durasevic I. Identifying Pex21p as a protein that specifically interacts with yeast seryl-tRNA synthetase. FEMS Microbiol Lett. 2002 Aug 27;214(1):101-6. PMID:12204379
  3. ↑ Stein K, Schell-Steven A, Erdmann R, Rottensteiner H. Interactions of Pex7p and Pex18p/Pex21p with the peroxisomal docking machinery: implications for the first steps in PTS2 protein import. Mol Cell Biol. 2002 Sep;22(17):6056-69. PMID:12167700
  4. ↑ Godinic V, Mocibob M, Rocak S, Ibba M, Weygand-Durasevic I. Peroxin Pex21p interacts with the C-terminal noncatalytic domain of yeast seryl-tRNA synthetase and forms a specific ternary complex with tRNA(Ser). FEBS J. 2007 Jun;274(11):2788-99. Epub 2007 Apr 20. PMID:17451428 doi:10.1111/j.1742-4658.2007.05812.x

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