3w9h

From Proteopedia

proteopedia linkproteopedia link

Revision as of 10:36, 19 June 2013 (edit) OCA (Talk | contribs) ← Previous diff		Revision as of 14:12, 3 July 2013 (edit) (undo) OCA (Talk | contribs) Next diff →
Line 1:		Line 1:
-	'''Unreleased structure'''	+	{{STRUCTURE_3w9h| PDB=3w9h | SCENE= }}
		+	===Structural basis for the inhibition of bacterial multidrug exporters===
-	The entry 3w9h is ON HOLD until Paper Publication	+	==Function==
		+	[[http://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI]] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>
-	Authors: Sakurai, K., Nagata, C., Nakashima, R., Yamaguchi, A.	+	==About this Structure==
		+	[[3w9h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W9H OCA].
-	Description: Structural basis for the inhibition of bacterial multidrug exporters	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Escherichia coli k-12]]
		+	[[Category: Nagata, C.]]
		+	[[Category: Nakashima, R.]]
		+	[[Category: Sakurai, K.]]
		+	[[Category: Yamaguchi, A.]]
		+	[[Category: Acra]]
		+	[[Category: Acrb]]
		+	[[Category: Efflux pump]]
		+	[[Category: Inner membrane]]
		+	[[Category: Membrane protein]]
		+	[[Category: Multidrug efflux pump]]
		+	[[Category: Tolc]]
		+	[[Category: Transport protein]]
		+	[[Category: Transporter]]

---

Revision as of 14:12, 3 July 2013

Template:STRUCTURE 3w9h

Contents 1 Structural basis for the inhibition of bacterial multidrug exporters 2 Function 3 About this Structure 4 Reference

Structural basis for the inhibition of bacterial multidrug exporters

Function

[ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.^{[1] [2] [3]}

About this Structure

3w9h is a 3 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Reference

1. ↑ Murakami S, Nakashima R, Yamashita E, Matsumoto T, Yamaguchi A. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature. 2006 Sep 14;443(7108):173-9. Epub 2006 Aug 16. PMID:16915237 doi:10.1038/nature05076
2. ↑ Seeger MA, Schiefner A, Eicher T, Verrey F, Diederichs K, Pos KM. Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism. Science. 2006 Sep 1;313(5791):1295-8. PMID:16946072 doi:313/5791/1295
3. ↑ Sennhauser G, Amstutz P, Briand C, Storchenegger O, Grutter MG. Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. PLoS Biol. 2007 Jan;5(1):e7. PMID:17194213 doi:10.1371/journal.pbio.0050007