This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4k69
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | [[4k69]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K69 OCA]. | + | [[4k69]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K69 OCA]. |
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:023659209</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:023659209</ref><references group="xtra"/><references/> | ||
[[Category: Chymase]] | [[Category: Chymase]] | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Collins, B K.]] | [[Category: Collins, B K.]] | ||
[[Category: Padyana, A K.]] | [[Category: Padyana, A K.]] | ||
Revision as of 14:29, 3 July 2013
Contents |
Crystal Structure of Human Chymase in Complex with Fragment Linked Benzimidazolone Inhibitor: (3S)-3-{3-[(6-bromo-2-oxo-2,3-dihydro-1H-indol-4-yl)methyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}hexanoic acid
Template:ABSTRACT PUBMED 23659209
Function
[CMA1_HUMAN] Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
About this Structure
4k69 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Taylor SJ, Padyana AK, Abeywardane A, Liang S, Hao MH, De Lombaert S, Proudfoot JR, Farmer BS, Li X, Collins B, Albaugh DR, Martin L, Hill-Drzewi M, Pullen SS, Takahashi H. Discovery of Potent, Selective Chymase Inhibitors via Fragment Linking Strategies. J Med Chem. 2013 May 9. PMID:23659209 doi:10.1021/jm400138z
