4hsu
From Proteopedia
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{{STRUCTURE_4hsu| PDB=4hsu | SCENE= }} | {{STRUCTURE_4hsu| PDB=4hsu | SCENE= }} | ||
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===Crystal structure of LSD2-NPAC with H3(1-26)in space group P21=== | ===Crystal structure of LSD2-NPAC with H3(1-26)in space group P21=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/GLYR1_HUMAN GLYR1_HUMAN]] May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3).<ref>PMID:16352664</ref> <ref>PMID:20850016</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[4hsu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSU OCA]. | [[4hsu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSU OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023357850</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Chen, F.]] | [[Category: Chen, F.]] | ||
Revision as of 14:19, 10 July 2013
Contents |
Crystal structure of LSD2-NPAC with H3(1-26)in space group P21
Function
[GLYR1_HUMAN] May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3).[1] [2]
About this Structure
4hsu is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Chen F, Yang H, Dong Z, Fang J, Wang P, Zhu T, Gong W, Fang R, Shi YG, Li Z, Xu Y. Structural insight into substrate recognition by histone demethylase LSD2/KDM1b. Cell Res. 2013 Feb;23(2):306-9. doi: 10.1038/cr.2013.17. Epub 2013 Jan 29. PMID:23357850 doi:10.1038/cr.2013.17
- ↑ Fu J, Yang Z, Wei J, Han J, Gu J. Nuclear protein NP60 regulates p38 MAPK activity. J Cell Sci. 2006 Jan 1;119(Pt 1):115-23. Epub 2005 Dec 13. PMID:16352664 doi:10.1242/jcs.02699
- ↑ Vermeulen M, Eberl HC, Matarese F, Marks H, Denissov S, Butter F, Lee KK, Olsen JV, Hyman AA, Stunnenberg HG, Mann M. Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell. 2010 Sep 17;142(6):967-80. doi: 10.1016/j.cell.2010.08.020. PMID:20850016 doi:10.1016/j.cell.2010.08.020
