4ixg

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==About this Structure==
==About this Structure==
[[4ixg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pneumocystis_carinii Pneumocystis carinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXG OCA].
[[4ixg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pneumocystis_carinii Pneumocystis carinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXG OCA].
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==Reference==
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<ref group="xtra">PMID:023627352</ref><references group="xtra"/><references/>
[[Category: Dihydrofolate reductase]]
[[Category: Dihydrofolate reductase]]
[[Category: Pneumocystis carinii]]
[[Category: Pneumocystis carinii]]

Revision as of 14:23, 10 July 2013

Template:STRUCTURE 4ixg

Contents

pcDHFR-268-K37S-N69F variant

Template:ABSTRACT PUBMED 23627352

Function

[DYR_PNECA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

About this Structure

4ixg is a 1 chain structure with sequence from Pneumocystis carinii. Full crystallographic information is available from OCA.

Reference

  • Gangjee A, Namjoshi OA, Raghavan S, Queener SF, Kisliuk RL, Cody V. Design, synthesis and molecular modeling of novel pyrido[2,3-d]pyrimidine analogs as antifolates: Application of Buchwald-Hartwig aminations of heterocycles. J Med Chem. 2013 Apr 29. PMID:23627352 doi:10.1021/jm400086g

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