4gv6
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
[[4gv6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lassa_virus_josiah Lassa virus josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV6 OCA]. | [[4gv6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lassa_virus_josiah Lassa virus josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV6 OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023615902</ref><references group="xtra"/><references/> | ||
[[Category: Lassa virus josiah]] | [[Category: Lassa virus josiah]] | ||
[[Category: Dong, C.]] | [[Category: Dong, C.]] | ||
Revision as of 14:24, 10 July 2013
Contents |
Structures of Lassa and Tacaribe viral nucleoproteins with or without 5 triphosphate dsRNA substrate reveal a unique 3 -5 exoribonuclease mechanism to suppress type I interferon production
Template:ABSTRACT PUBMED 23615902
Function
[NCAP_LASSJ] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity).
About this Structure
4gv6 is a 3 chain structure with sequence from Lassa virus josiah. Full crystallographic information is available from OCA.
Reference
- Jiang X, Huang Q, Wang W, Dong H, Ly H, Liang Y, Dong C. Structures of arenaviral nucleoproteins with triphosphate dsRNA reveal a unique mechanism of immune suppression. J Biol Chem. 2013 Apr 24. PMID:23615902 doi:10.1074/jbc.M112.420521
