3u3q

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'''Unreleased structure'''
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{{STRUCTURE_3u3q| PDB=3u3q | SCENE= }}
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===The S-SAD phased crystal structure of the ecto-domain of Death Receptor 6 (DR6)===
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{{ABSTRACT_PUBMED_22525750}}
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The entry 3u3q is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/TNR21_HUMAN TNR21_HUMAN]] May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
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Authors: Ru, H., Zhao, L.X., Ding, W., Jiao, L.Y., Shaw, N., Zhang, L.G., Hung, L.W., Matsugaki, N., Wakatsuki, S., Liu, Z.J.
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==About this Structure==
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[[3u3q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3Q OCA].
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Description: The S-SAD phased crystal structure of Death Receptor 6 (DR6) and its solution conformation revealed by SAXS
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==Reference==
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<ref group="xtra">PMID:022525750</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Ding, W.]]
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[[Category: Hung, L W.]]
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[[Category: Jiao, L Y.]]
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[[Category: Liu, Z J.]]
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[[Category: Matsugaki, N.]]
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[[Category: Ru, H.]]
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[[Category: Shaw, N.]]
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[[Category: Wakatsuki, S.]]
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[[Category: Zhang, L G.]]
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[[Category: Zhao, L X.]]
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[[Category: Apoptosis]]
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[[Category: Trigger apoptosis]]

Revision as of 14:28, 10 July 2013

Template:STRUCTURE 3u3q

Contents

The S-SAD phased crystal structure of the ecto-domain of Death Receptor 6 (DR6)

Template:ABSTRACT PUBMED 22525750

Function

[TNR21_HUMAN] May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).

About this Structure

3u3q is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Ru H, Zhao L, Ding W, Jiao L, Shaw N, Liang W, Zhang L, Hung LW, Matsugaki N, Wakatsuki S, Liu ZJ. S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS. Acta Crystallogr D Biol Crystallogr. 2012 May;68(Pt 5):521-30. Epub 2012 Apr 17. PMID:22525750 doi:10.1107/S0907444912004490

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OCA

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