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4gc5

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'''Unreleased structure'''
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{{STRUCTURE_4gc5| PDB=4gc5 | SCENE= }}
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===Crystal structure of murine TFB1M===
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{{ABSTRACT_PUBMED_23804760}}
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The entry 4gc5 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/TFB1M_MOUSE TFB1M_MOUSE]] S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity).
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Authors: Guja, K.E., Yakubovskaya, E., Shi, H., Mejia, E., Hambardjieva, E., Venkataraman, K., Karzai, A.W., Garcia-Diaz, M.
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==About this Structure==
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[[4gc5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GC5 OCA].
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Description: Crystal structure of murine TFB1M
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==Reference==
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<ref group="xtra">PMID:023804760</ref><references group="xtra"/><references/>
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[[Category: Mus musculus]]
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[[Category: Garcia-Diaz, M.]]
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[[Category: Guja, K E.]]
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[[Category: Hambardjieva, E.]]
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[[Category: Karzai, A W.]]
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[[Category: Mejia, E.]]
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[[Category: Shi, H.]]
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[[Category: Venkataraman, K.]]
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[[Category: Yakubovskaya, E.]]
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[[Category: Methylation]]
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[[Category: Methyltransferase fold]]
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[[Category: Mitochondria]]
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[[Category: Rrna methyltransferase]]
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[[Category: Transferase]]

Revision as of 15:36, 10 July 2013

Template:STRUCTURE 4gc5

Contents

Crystal structure of murine TFB1M

Template:ABSTRACT PUBMED 23804760

Function

[TFB1M_MOUSE] S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity).

About this Structure

4gc5 is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Guja KE, Venkataraman K, Yakubovskaya E, Shi H, Mejia E, Hambardjieva E, Karzai AW, Garcia-Diaz M. Structural basis for S-adenosylmethionine binding and methyltransferase activity by mitochondrial transcription factor B1. Nucleic Acids Res. 2013 Jun 26. PMID:23804760 doi:10.1093/nar/gkt547

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OCA

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