4gr9

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'''Unreleased structure'''
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{{STRUCTURE_4gr9| PDB=4gr9 | SCENE= }}
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===Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation===
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{{ABSTRACT_PUBMED_23131339}}
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The entry 4gr9 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
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Authors: Volkova, M.S., Jensen, K.C., Lozinskaya, N.A., Sosonyuk, S.E., Proskurnina, M.V., Mesecar, A.D., Zefirov, N.S.
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==About this Structure==
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[[4gr9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GR9 OCA].
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Description: Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation
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==Reference==
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<ref group="xtra">PMID:023131339</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Jensen, K C.]]
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[[Category: Lozinskaya, N A.]]
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[[Category: Mesecar, A D.]]
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[[Category: Proskurnina, M V.]]
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[[Category: Sosonyuk, S E.]]
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[[Category: Volkova, M S.]]
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[[Category: Zefirov, N S.]]
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[[Category: Melatonin analog]]
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[[Category: Oxidoreductase]]

Revision as of 15:37, 10 July 2013

Template:STRUCTURE 4gr9

Contents

Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation

Template:ABSTRACT PUBMED 23131339

Function

[NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.[1]

About this Structure

4gr9 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Volkova MS, Jensen KC, Lozinskaya NA, Sosonyuk SE, Proskurnina MV, Mesecar AD, Zefirov NS. Synthesis of novel capital EM, Cyrilliccapital TE, Cyrillic3 receptor ligands via an unusual Knoevenagel condensation. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7578-81. doi:, 10.1016/j.bmcl.2012.10.005. Epub 2012 Oct 17. PMID:23131339 doi:10.1016/j.bmcl.2012.10.005
  1. ↑ Calamini B, Santarsiero BD, Boutin JA, Mesecar AD. Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2. Biochem J. 2008 Jul 1;413(1):81-91. PMID:18254726 doi:10.1042/BJ20071373

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