4kp6

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m (Protected "4kp6" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4kp6| PDB=4kp6 | SCENE= }}
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===Crystal structure of human phosphodiesterase 4B (PDE4B) in complex with a [1,3,5]triazine derivative===
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{{ABSTRACT_PUBMED_23806553}}
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The entry 4kp6 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref>
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Authors: Gewald, R., Grunwald, C., Egerland, U.
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==About this Structure==
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[[4kp6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KP6 OCA].
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Description: Crystal structure of human phosphodiesterase 4B (PDE4B) in complex with a [1,3,5]triazine derivative
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==Reference==
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<ref group="xtra">PMID:023806553</ref><references group="xtra"/><references/>
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[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
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[[Category: Homo sapiens]]
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[[Category: Egerland, U.]]
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[[Category: Gewald, R.]]
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[[Category: Grunwald, C.]]
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[[Category: Copd]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Neutrophilia]]
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[[Category: Pde4 inhibitor]]
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[[Category: Phosphodiesterase]]
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[[Category: Triazine]]

Revision as of 15:38, 10 July 2013

Template:STRUCTURE 4kp6

Contents

Crystal structure of human phosphodiesterase 4B (PDE4B) in complex with a [1,3,5]triazine derivative

Template:ABSTRACT PUBMED 23806553

Function

[PDE4B_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.[1] [2]

About this Structure

4kp6 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Gewald R, Grunwald C, Egerland U. Discovery of triazines as potent, selective and orally active PDE4 inhibitors. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4308-14. doi: 10.1016/j.bmcl.2013.05.099., Epub 2013 Jun 10. PMID:23806553 doi:10.1016/j.bmcl.2013.05.099
  1. ↑ Xu RX, Hassell AM, Vanderwall D, Lambert MH, Holmes WD, Luther MA, Rocque WJ, Milburn MV, Zhao Y, Ke H, Nolte RT. Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity. Science. 2000 Jun 9;288(5472):1822-5. PMID:10846163
  2. ↑ Xu RX, Rocque WJ, Lambert MH, Vanderwall DE, Luther MA, Nolte RT. Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram. J Mol Biol. 2004 Mar 19;337(2):355-65. PMID:15003452 doi:http://dx.doi.org/10.1016/j.jmb.2004.01.040

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