3zl1

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'''Unreleased structure'''
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{{STRUCTURE_3zl1| PDB=3zl1 | SCENE= }}
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===A thiazolyl-mannoside bound to FimH, monoclinic space group===
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{{ABSTRACT_PUBMED_23795713}}
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The entry 3zl1 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/FIMH_ECOLI FIMH_ECOLI]] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.
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Authors: Brument, S., Sivignon, A., Dumych, T.I., Moreau, N., Roos, G., Guerardel, Y., Chalopin, T., Deniaud, D., Bilyy, R.O., Darfeuille-Michaud, A., Bouckaert, J., Gouin, S.G.
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==About this Structure==
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[[3zl1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_j96 Escherichia coli j96]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZL1 OCA].
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Description: A thiazolyl-mannoside bound to FimH, monoclinic space group
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==Reference==
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<ref group="xtra">PMID:023795713</ref><references group="xtra"/><references/>
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[[Category: Escherichia coli j96]]
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[[Category: Bilyy, R O.]]
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[[Category: Bouckaert, J.]]
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[[Category: Brument, S.]]
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[[Category: Chalopin, T.]]
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[[Category: Darfeuille-Michaud, A.]]
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[[Category: Deniaud, D.]]
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[[Category: Dumych, T I.]]
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[[Category: Gouin, S G.]]
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[[Category: Guerardel, Y.]]
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[[Category: Moreau, N.]]
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[[Category: Roos, G.]]
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[[Category: Sivignon, A.]]
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[[Category: Cell adhesion]]
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[[Category: Crohn's disease]]
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[[Category: Immunoglobulin]]
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[[Category: Thiazole]]
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[[Category: Type-1 fimbriae]]

Revision as of 15:40, 10 July 2013

Template:STRUCTURE 3zl1

Contents

A thiazolyl-mannoside bound to FimH, monoclinic space group

Template:ABSTRACT PUBMED 23795713

Function

[FIMH_ECOLI] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.

About this Structure

3zl1 is a 2 chain structure with sequence from Escherichia coli j96. Full crystallographic information is available from OCA.

Reference

  • Brument S, Sivignon A, Dumych TI, Moreau N, Roos G, Guerardel Y, Chalopin T, Deniaud D, Bilyy RO, Darfeuille-Michaud A, Bouckaert J, Gouin SG. Thiazolylaminomannosides As Potent Antiadhesives of Type 1 Piliated Escherichia coli Isolated from Crohn's Disease Patients. J Med Chem. 2013 Jun 24. PMID:23795713 doi:10.1021/jm400723n

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