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3zl2
From Proteopedia
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| - | + | {{STRUCTURE_3zl2| PDB=3zl2 | SCENE= }} | |
| + | ===A thiazolyl-mannoside bound to FimH, orthorhombic space group=== | ||
| + | {{ABSTRACT_PUBMED_23795713}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/FIMH_ECOLI FIMH_ECOLI]] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed. | ||
| - | + | ==About this Structure== | |
| + | [[3zl2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_j96 Escherichia coli j96]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZL2 OCA]. | ||
| - | + | ==Reference== | |
| + | <ref group="xtra">PMID:023795713</ref><references group="xtra"/><references/> | ||
| + | [[Category: Escherichia coli j96]] | ||
| + | [[Category: Bilyy, R O.]] | ||
| + | [[Category: Bouckaert, J.]] | ||
| + | [[Category: Brument, S.]] | ||
| + | [[Category: Chalopin, T.]] | ||
| + | [[Category: Darfeuille-Michaud, A.]] | ||
| + | [[Category: Deniaud, D.]] | ||
| + | [[Category: Dumych, T I.]] | ||
| + | [[Category: Gouin, S G.]] | ||
| + | [[Category: Guerardel, Y.]] | ||
| + | [[Category: Moreau, N.]] | ||
| + | [[Category: Roos, G.]] | ||
| + | [[Category: Sivignon, A.]] | ||
| + | [[Category: Cell adhesion]] | ||
| + | [[Category: Crohn's disease]] | ||
| + | [[Category: Immunoglobulin]] | ||
| + | [[Category: Thiazole]] | ||
| + | [[Category: Type-1 fimbriae]] | ||
Revision as of 15:40, 10 July 2013
Contents |
A thiazolyl-mannoside bound to FimH, orthorhombic space group
Template:ABSTRACT PUBMED 23795713
Function
[FIMH_ECOLI] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.
About this Structure
3zl2 is a 1 chain structure with sequence from Escherichia coli j96. Full crystallographic information is available from OCA.
Reference
- Brument S, Sivignon A, Dumych TI, Moreau N, Roos G, Guerardel Y, Chalopin T, Deniaud D, Bilyy RO, Darfeuille-Michaud A, Bouckaert J, Gouin SG. Thiazolylaminomannosides As Potent Antiadhesives of Type 1 Piliated Escherichia coli Isolated from Crohn's Disease Patients. J Med Chem. 2013 Jun 24. PMID:23795713 doi:10.1021/jm400723n
