2if7
From Proteopedia
(New page: 200px<br /> <applet load="2if7" size="450" color="white" frame="true" align="right" spinBox="true" caption="2if7, resolution 3.000Å" /> '''Crystal Structure ...) |
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| - | [[Image:2if7.gif|left|200px]]<br /> | + | [[Image:2if7.gif|left|200px]]<br /><applet load="2if7" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2if7" size=" | + | |
caption="2if7, resolution 3.000Å" /> | caption="2if7, resolution 3.000Å" /> | ||
'''Crystal Structure of NTB-A'''<br /> | '''Crystal Structure of NTB-A'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The signaling lymphocytic activation molecule (SLAM) family includes | + | The signaling lymphocytic activation molecule (SLAM) family includes homophilic and heterophilic receptors that regulate both innate and adaptive immunity. The ectodomains of most SLAM family members are composed of an N-terminal IgV domain and a C-terminal IgC2 domain. NK-T-B-antigen (NTB-A) is a homophilic receptor that stimulates cytotoxicity in natural killer (NK) cells, regulates bactericidal activities in neutrophils, and potentiates T helper 2 (Th2) responses. The 3.0 A crystal structure of the complete NTB-A ectodomain revealed a rod-like monomer that self-associates to form a highly kinked dimer spanning an end-to-end distance of approximately 100 A. The NTB-A homophilic and CD2-CD58 heterophilic dimers show overall structural similarities but differ in detailed organization and physicochemical properties of their respective interfaces. The NTB-A structure suggests a mechanism responsible for binding specificity within the SLAM family and imposes physical constraints relevant to the colocalization of SLAM-family proteins with other signaling molecules in the immunological synapse. |
==About this Structure== | ==About this Structure== | ||
| - | 2IF7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CL and CA as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 2IF7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IF7 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Almo, S | + | [[Category: Almo, S C.]] |
[[Category: Cao, E.]] | [[Category: Cao, E.]] | ||
| - | [[Category: Fedorov, A | + | [[Category: Fedorov, A A.]] |
| - | [[Category: Fedorov, E | + | [[Category: Fedorov, E V.]] |
| - | [[Category: Nathenson, S | + | [[Category: Nathenson, S G.]] |
| - | [[Category: Ramagopal, U | + | [[Category: Ramagopal, U A.]] |
[[Category: CA]] | [[Category: CA]] | ||
[[Category: CL]] | [[Category: CL]] | ||
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[[Category: slam6]] | [[Category: slam6]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:52:03 2008'' |
Revision as of 15:52, 21 February 2008
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Crystal Structure of NTB-A
Overview
The signaling lymphocytic activation molecule (SLAM) family includes homophilic and heterophilic receptors that regulate both innate and adaptive immunity. The ectodomains of most SLAM family members are composed of an N-terminal IgV domain and a C-terminal IgC2 domain. NK-T-B-antigen (NTB-A) is a homophilic receptor that stimulates cytotoxicity in natural killer (NK) cells, regulates bactericidal activities in neutrophils, and potentiates T helper 2 (Th2) responses. The 3.0 A crystal structure of the complete NTB-A ectodomain revealed a rod-like monomer that self-associates to form a highly kinked dimer spanning an end-to-end distance of approximately 100 A. The NTB-A homophilic and CD2-CD58 heterophilic dimers show overall structural similarities but differ in detailed organization and physicochemical properties of their respective interfaces. The NTB-A structure suggests a mechanism responsible for binding specificity within the SLAM family and imposes physical constraints relevant to the colocalization of SLAM-family proteins with other signaling molecules in the immunological synapse.
About this Structure
2IF7 is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family., Cao E, Ramagopal UA, Fedorov A, Fedorov E, Yan Q, Lary JW, Cole JL, Nathenson SG, Almo SC, Immunity. 2006 Oct;25(4):559-70. PMID:17045824
Page seeded by OCA on Thu Feb 21 17:52:03 2008
Categories: Homo sapiens | Single protein | Almo, S C. | Cao, E. | Fedorov, A A. | Fedorov, E V. | Nathenson, S G. | Ramagopal, U A. | CA | CL | Homophilic receptor | Ly108 | Ntb-a | Slam6
