4kso

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'''Unreleased structure'''
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{{STRUCTURE_4kso| PDB=4kso | SCENE= }}
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===Crystal Structure of Circadian clock protein KaiB from S.Elongatus===
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{{ABSTRACT_PUBMED_23796516}}
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The entry 4kso is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/KAIB_SYNE7 KAIB_SYNE7]] Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-non-specific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it decreases the phosphorylation status of KaiC. It has no effect on KaiC by itself, but instead need the presence of both KaiA and KaiC, suggesting that it acts by antagonizing the interaction between KaiA and KaiC.<ref>PMID:9727980</ref> <ref>PMID:12727878</ref> <ref>PMID:12727879</ref> <ref>PMID:14709675</ref>
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Authors: Pattanayek, R., Egli, M.
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==About this Structure==
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[[4kso]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus_pcc_7942 Synechococcus elongatus pcc 7942]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSO OCA].
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Description: Crystal Structure of Circadian clock protein KaiB from S.Elongatus
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==Reference==
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<ref group="xtra">PMID:023796516</ref><references group="xtra"/><references/>
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[[Category: Synechococcus elongatus pcc 7942]]
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[[Category: Egli, M.]]
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[[Category: Pattanayek, R.]]
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[[Category: Circadian clock]]
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[[Category: Circadian clock protein]]
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[[Category: Cyanobacterial circadian clock protein kaib]]
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[[Category: Kaic protein]]
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[[Category: Soluble]]

Revision as of 15:44, 10 July 2013

Template:STRUCTURE 4kso

Contents

Crystal Structure of Circadian clock protein KaiB from S.Elongatus

Template:ABSTRACT PUBMED 23796516

Function

[KAIB_SYNE7] Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-non-specific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it decreases the phosphorylation status of KaiC. It has no effect on KaiC by itself, but instead need the presence of both KaiA and KaiC, suggesting that it acts by antagonizing the interaction between KaiA and KaiC.[1] [2] [3] [4]

About this Structure

4kso is a 4 chain structure with sequence from Synechococcus elongatus pcc 7942. Full crystallographic information is available from OCA.

Reference

  • Villarreal SA, Pattanayek R, Williams DR, Mori T, Qin X, Johnson CH, Egli M, Stewart PL. CryoEM and Molecular Dynamics of the Circadian KaiB-KaiC Complex Indicates KaiB Monomers Interact with KaiC and Block ATP Binding Clefts. J Mol Biol. 2013 Jun 21. pii: S0022-2836(13)00397-5. doi:, 10.1016/j.jmb.2013.06.018. PMID:23796516 doi:10.1016/j.jmb.2013.06.018
  1. ↑ Ishiura M, Kutsuna S, Aoki S, Iwasaki H, Andersson CR, Tanabe A, Golden SS, Johnson CH, Kondo T. Expression of a gene cluster kaiABC as a circadian feedback process in cyanobacteria. Science. 1998 Sep 4;281(5382):1519-23. PMID:9727980
  2. ↑ Xu Y, Mori T, Johnson CH. Cyanobacterial circadian clockwork: roles of KaiA, KaiB and the kaiBC promoter in regulating KaiC. EMBO J. 2003 May 1;22(9):2117-26. PMID:12727878 doi:10.1093/emboj/cdg168
  3. ↑ Kitayama Y, Iwasaki H, Nishiwaki T, Kondo T. KaiB functions as an attenuator of KaiC phosphorylation in the cyanobacterial circadian clock system. EMBO J. 2003 May 1;22(9):2127-34. PMID:12727879 doi:10.1093/emboj/cdg212
  4. ↑ Nakahira Y, Katayama M, Miyashita H, Kutsuna S, Iwasaki H, Oyama T, Kondo T. Global gene repression by KaiC as a master process of prokaryotic circadian system. Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):881-5. Epub 2004 Jan 6. PMID:14709675 doi:10.1073/pnas.0307411100

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