3zhf

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'''Unreleased structure'''
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{{STRUCTURE_3zhf| PDB=3zhf | SCENE= }}
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===gamma 2 adaptin EAR domain crystal structure with preS1 site1 peptide NPDWDFN===
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The entry 3zhf is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/AP1G2_HUMAN AP1G2_HUMAN]] May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV).<ref>PMID:9733768</ref> <ref>PMID:16867982</ref> <ref>PMID:17553870</ref> [[http://www.uniprot.org/uniprot/Q67953_HBV Q67953_HBV]] The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid (By similarity).[SAAS:SAAS000349_004_055156]
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Authors: Juergens, M.C., Voros, J., Rautureau, G., Shepherd, D., Pye, V.E., Muldoon, J., Johnson, C.M., Ashcroft, A., Freund, S.M.V., Ferguson, N.
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==About this Structure==
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[[3zhf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZHF OCA].
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Description: gamma 2 adaptin EAR domain crystal structure with preS1 site1 peptide NPDWDFN
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Escherichia coli]]
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[[Category: Ashcroft, A.]]
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[[Category: Ferguson, N.]]
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[[Category: Freund, S M.V.]]
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[[Category: Johnson, C M.]]
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[[Category: Juergens, M C.]]
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[[Category: Muldoon, J.]]
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[[Category: Pye, V E.]]
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[[Category: Rautureau, G.]]
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[[Category: Shepherd, D.]]
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[[Category: Voros, J.]]
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[[Category: Gae]]
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[[Category: Protein transport-viral protein complex]]

Revision as of 15:48, 10 July 2013

Template:STRUCTURE 3zhf

Contents

gamma 2 adaptin EAR domain crystal structure with preS1 site1 peptide NPDWDFN

Function

[AP1G2_HUMAN] May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV).[1] [2] [3] [Q67953_HBV] The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid (By similarity).[SAAS:SAAS000349_004_055156]

About this Structure

3zhf is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

  1. ↑ Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K. Identification and characterization of novel clathrin adaptor-related proteins. J Biol Chem. 1998 Sep 18;273(38):24693-700. PMID:9733768
  2. ↑ Rost M, Mann S, Lambert C, Doring T, Thome N, Prange R. Gamma-adaptin, a novel ubiquitin-interacting adaptor, and Nedd4 ubiquitin ligase control hepatitis B virus maturation. J Biol Chem. 2006 Sep 29;281(39):29297-308. Epub 2006 Jul 25. PMID:16867982 doi:M603517200
  3. ↑ Lambert C, Doring T, Prange R. Hepatitis B virus maturation is sensitive to functional inhibition of ESCRT-III, Vps4, and gamma 2-adaptin. J Virol. 2007 Sep;81(17):9050-60. Epub 2007 Jun 6. PMID:17553870 doi:JVI.00479-07

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OCA

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