4fzs

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'''Unreleased structure'''
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{{STRUCTURE_4fzs| PDB=4fzs | SCENE= }}
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===Structure of human SNX1 BAR domain===
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The entry 4fzs is ON HOLD until Jul 04 2014
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==Function==
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[[http://www.uniprot.org/uniprot/SNX1_HUMAN SNX1_HUMAN]] May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).<ref>PMID:12198132</ref> <ref>PMID:15498486</ref> <ref>PMID:17101778</ref>
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Authors: van Weering, J.R.T., Sessions, R.B., Traer, C.J., Kloer, D.P., Bhatia, V.K., Stamou, D., Hurley, J.H., Cullen, P.J.
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==About this Structure==
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[[4fzs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZS OCA].
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Description: Structure of human SNX1 BAR domain
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Bhatia, V K.]]
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[[Category: Cullen, P J.]]
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[[Category: Hurley, J H.]]
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[[Category: Kloer, D P.]]
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[[Category: Sessions, R B.]]
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[[Category: Stamou, D.]]
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[[Category: Traer, C J.]]
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[[Category: Weering, J R.T van.]]
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[[Category: Bar]]
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[[Category: Membrane remodeling]]
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[[Category: Protein transport]]

Revision as of 15:51, 10 July 2013

Template:STRUCTURE 4fzs

Contents

Structure of human SNX1 BAR domain

Function

[SNX1_HUMAN] May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).[1] [2] [3]

About this Structure

4fzs is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Cozier GE, Carlton J, McGregor AH, Gleeson PA, Teasdale RD, Mellor H, Cullen PJ. The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation. J Biol Chem. 2002 Dec 13;277(50):48730-6. Epub 2002 Aug 26. PMID:12198132 doi:10.1074/jbc.M206986200
  2. ↑ Carlton J, Bujny M, Peter BJ, Oorschot VM, Rutherford A, Mellor H, Klumperman J, McMahon HT, Cullen PJ. Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides. Curr Biol. 2004 Oct 26;14(20):1791-800. PMID:15498486 doi:10.1016/j.cub.2004.09.077
  3. ↑ Rojas R, Kametaka S, Haft CR, Bonifacino JS. Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. Mol Cell Biol. 2007 Feb;27(3):1112-24. Epub 2006 Nov 13. PMID:17101778 doi:10.1128/MCB.00156-06

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