4kgq

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-	'''Unreleased structure'''	+	{{STRUCTURE_4kgq| PDB=4kgq | SCENE= }}
		+	===Crystal structure of a human light loop mutant in complex with dcr3===
-	The entry 4kgq is ON HOLD	+	==Function==
		+	[[http://www.uniprot.org/uniprot/TNF6B_HUMAN TNF6B_HUMAN]] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.<ref>PMID:21300286</ref> [[http://www.uniprot.org/uniprot/TNF14_HUMAN TNF14_HUMAN]] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
-	Authors: Liu, W., Zhan, C., Bonanno, J.B., Sampathkumar, P., Toro, R., Nathenson, S.G., Almo, S.C., New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN)	+	==About this Structure==
		+	[[4kgq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KGQ OCA].
-	Description: Crystal structure of a human light loop mutant in complex with dcr3	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Almo, S C.]]
		+	[[Category: Bonanno, J B.]]
		+	[[Category: IFN, Atoms-to-Animals:.The Immune Function Network.]]
		+	[[Category: Liu, W.]]
		+	[[Category: NYSGRC, New York Structural Genomics Research Consortium.]]
		+	[[Category: Nathenson, S G.]]
		+	[[Category: Sampathkumar, P.]]
		+	[[Category: Toro, R.]]
		+	[[Category: Zhan, C.]]
		+	[[Category: Atoms-to-animals: the immune function network]]
		+	[[Category: Bind tnf receptor hvem and ltbr]]
		+	[[Category: Cytokine]]
		+	[[Category: Dcr3]]
		+	[[Category: Ifn]]
		+	[[Category: Immune system]]
		+	[[Category: Jelly-roll fold]]
		+	[[Category: Light]]
		+	[[Category: Ltbr]]
		+	[[Category: Membrane]]
		+	[[Category: N-glycosylation]]
		+	[[Category: New hvem]]
		+	[[Category: New york structural genomics research consortium]]
		+	[[Category: Nysgrc]]
		+	[[Category: Protein structure initiative]]
		+	[[Category: Psi-biology]]
		+	[[Category: Secreted protein]]
		+	[[Category: Structural genomic]]
		+	[[Category: Tnf]]
		+	[[Category: Tnf14]]
		+	[[Category: Tnfr]]

---

Revision as of 15:54, 10 July 2013

Template:STRUCTURE 4kgq

Contents 1 Crystal structure of a human light loop mutant in complex with dcr3 2 Function 3 About this Structure 4 Reference

Crystal structure of a human light loop mutant in complex with dcr3

Function

[TNF6B_HUMAN] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.^[1] [TNF14_HUMAN] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.

About this Structure

4kgq is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

1. ↑ Zhan C, Patskovsky Y, Yan Q, Li Z, Ramagopal U, Cheng H, Brenowitz M, Hui X, Nathenson SG, Almo SC. Decoy Strategies: The Structure of TL1A:DcR3 Complex. Structure. 2011 Feb 9;19(2):162-71. PMID:21300286 doi:10.1016/j.str.2010.12.004