4lg2

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m (Protected "4lg2" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4lg2| PDB=4lg2 | SCENE= }}
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===Crystal structure of Reston Ebola virus VP35 RNA binding domain bound to 12-bp dsRNA===
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The entry 4lg2 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/VP35_EBORR VP35_EBORR]] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).
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Authors: Bale, S., Julien, J-P., Bornholdt, Z.A., Krois, A.S., Wilson, I.A., Saphire. E.O.
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==About this Structure==
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[[4lg2]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Reston_ebolavirus_-_reston_(1989) Reston ebolavirus - reston (1989)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG2 OCA].
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Description: Crystal structure of Reston Ebola virus VP35 RNA binding domain bound to 12-bp dsRNA
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[[Category: Bale, S.]]
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[[Category: Bornholdt, Z A.]]
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[[Category: E O., Saphire..]]
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[[Category: Julien, J-P.]]
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[[Category: Krois, A S.]]
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[[Category: Wilson, I A.]]
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[[Category: Dsrna]]
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[[Category: Dsrna binding protein]]
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[[Category: Rna binding domain]]
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[[Category: Rna binding protein-rna complex]]

Revision as of 15:57, 10 July 2013

Template:STRUCTURE 4lg2

Crystal structure of Reston Ebola virus VP35 RNA binding domain bound to 12-bp dsRNA

Function

[VP35_EBORR] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).

About this Structure

4lg2 is a 8 chain structure with sequence from Reston ebolavirus - reston (1989). Full crystallographic information is available from OCA.

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OCA

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