Tumor necrosis factor (TNF) is a cytokine which can cause apoptosis. TNFα is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNF alpha converting enzyme (TACE or ADAM17 see A Disintegrin And Metalloproteinase).
3D Structures of tumor necrosis factor
Updated on 11-July-2013
TNF alpha
1tnf – hTNF – human
2tun, 1a8m, 4tsv, 5tsw, 2e7e, 2zjc, 2zpx – hTNF (mutant)
2tnf – TNF – mouse
2az5 – hTNF + inhibitor
3it8 – hTNF + poxvirus 2L protein
3l9j – hTNF + antagonist
3alq – hTNF (mutant) + TNF receptor
4g3y – hTNF + antibody
