4ga7

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[[Image:4ga7.jpg|left|200px]]
 
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{{STRUCTURE_4ga7| PDB=4ga7 | SCENE= }}
{{STRUCTURE_4ga7| PDB=4ga7 | SCENE= }}
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===Crystal structure of human serpinB1 mutant===
===Crystal structure of human serpinB1 mutant===
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{{ABSTRACT_PUBMED_23269243}}
{{ABSTRACT_PUBMED_23269243}}
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==Function==
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[[http://www.uniprot.org/uniprot/ILEU_HUMAN ILEU_HUMAN]] Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H.<ref>PMID:11747453</ref>
==About this Structure==
==About this Structure==
[[4ga7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA7 OCA].
[[4ga7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA7 OCA].
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==Reference==
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<ref group="xtra">PMID:023269243</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Fan, Z.]]
[[Category: Fan, Z.]]

Revision as of 04:10, 18 July 2013

Template:STRUCTURE 4ga7

Contents

Crystal structure of human serpinB1 mutant

Template:ABSTRACT PUBMED 23269243

Function

[ILEU_HUMAN] Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H.[1]

About this Structure

4ga7 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Wang L, Li Q, Wu L, Liu S, Zhang Y, Yang X, Zhu P, Zhang H, Zhang K, Lou J, Liu P, Tong L, Sun F, Fan Z. Identification of SERPINB1 As a Physiological Inhibitor of Human Granzyme H. J Immunol. 2012 Dec 26. PMID:23269243 doi:10.4049/jimmunol.1202542
  1. ↑ Cooley J, Takayama TK, Shapiro SD, Schechter NM, Remold-O'Donnell E. The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites. Biochemistry. 2001 Dec 25;40(51):15762-70. PMID:11747453

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