4enf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:4enf.jpg|left|200px]]
 
- 
{{STRUCTURE_4enf| PDB=4enf | SCENE= }}
{{STRUCTURE_4enf| PDB=4enf | SCENE= }}
- 
===Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Puerto Rico/8/34(h1n1)===
===Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Puerto Rico/8/34(h1n1)===
 +
{{ABSTRACT_PUBMED_23436652}}
 +
==Function==
 +
[[http://www.uniprot.org/uniprot/PB2_I34A1 PB2_I34A1]] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity).
==About this Structure==
==About this Structure==
[[4enf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/1934(h1n1)) Influenza a virus (a/puerto rico/8/1934(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ENF OCA].
[[4enf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/1934(h1n1)) Influenza a virus (a/puerto rico/8/1934(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ENF OCA].
 +
 +
==Reference==
 +
<ref group="xtra">PMID:023436652</ref><references group="xtra"/><references/>
[[Category: Liu, Y.]]
[[Category: Liu, Y.]]
[[Category: Meng, G.]]
[[Category: Meng, G.]]

Revision as of 04:13, 18 July 2013

Template:STRUCTURE 4enf

Contents

Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Puerto Rico/8/34(h1n1)

Template:ABSTRACT PUBMED 23436652

Function

[PB2_I34A1] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity).

About this Structure

4enf is a 1 chain structure with sequence from Influenza a virus (a/puerto rico/8/1934(h1n1)). Full crystallographic information is available from OCA.

Reference

  • Liu Y, Qin K, Meng G, Zhang J, Zhou J, Zhao G, Luo M, Zheng X. Structural and functional characterization of K339T substitution identified in the PB2 subunit cap-binding pocket of influenza A virus. J Biol Chem. 2013 Apr 19;288(16):11013-23. doi: 10.1074/jbc.M112.392878. Epub, 2013 Feb 22. PMID:23436652 doi:10.1074/jbc.M112.392878

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4enf"
Personal tools