4gaw

From Proteopedia

Revision as of 04:33, 18 July 2013

Template:STRUCTURE 4gaw

Crystal structure of active human granzyme H

Template:ABSTRACT PUBMED 23269243

Function

[GRAH_HUMAN] Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.^{[1] [2]}

About this Structure

4gaw is a 12 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Wang L, Li Q, Wu L, Liu S, Zhang Y, Yang X, Zhu P, Zhang H, Zhang K, Lou J, Liu P, Tong L, Sun F, Fan Z. Identification of SERPINB1 As a Physiological Inhibitor of Human Granzyme H. J Immunol. 2012 Dec 26. PMID:23269243 doi:10.4049/jimmunol.1202542

1. ↑ Wang L, Zhang K, Wu L, Liu S, Zhang H, Zhou Q, Tong L, Sun F, Fan Z. Structural Insights into the Substrate Specificity of Human Granzyme H: The Functional Roles of a Novel RKR Motif. J Immunol. 2011 Dec 9. PMID:22156497 doi:10.4049/jimmunol.1101381
2. ↑ Wang L, Li Q, Wu L, Liu S, Zhang Y, Yang X, Zhu P, Zhang H, Zhang K, Lou J, Liu P, Tong L, Sun F, Fan Z. Identification of SERPINB1 As a Physiological Inhibitor of Human Granzyme H. J Immunol. 2012 Dec 26. PMID:23269243 doi:10.4049/jimmunol.1202542