1oe5
From Proteopedia
(Difference between revisions)
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| - | [[Image:1oe5.png|left|200px]] | ||
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{{STRUCTURE_1oe5| PDB=1oe5 | SCENE= }} | {{STRUCTURE_1oe5| PDB=1oe5 | SCENE= }} | ||
| + | ===Xenopus SMUG1, an anti-mutator uracil-DNA Glycosylase=== | ||
| + | {{ABSTRACT_PUBMED_12820976}} | ||
| - | === | + | ==Function== |
| - | + | [[http://www.uniprot.org/uniprot/SMUG1_XENLA SMUG1_XENLA]] Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. No enzymatic activity towards G/T mismatches. | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:012820976</ref><references group="xtra"/> | + | <ref group="xtra">PMID:012820976</ref><references group="xtra"/><references/> |
[[Category: Xenopus laevis]] | [[Category: Xenopus laevis]] | ||
[[Category: Pearl, L H.]] | [[Category: Pearl, L H.]] | ||
[[Category: Wibley, J E.A.]] | [[Category: Wibley, J E.A.]] | ||
[[Category: Dna glycosylase]] | [[Category: Dna glycosylase]] | ||
| - | + | [[Category: Hydrolase-dna complex]] | |
| - | [[Category: Hydrolase-complex]] | + | |
[[Category: Single stranded]] | [[Category: Single stranded]] | ||
| - | [[Category: Smug1]] | ||
Revision as of 04:36, 18 July 2013
Contents |
Xenopus SMUG1, an anti-mutator uracil-DNA Glycosylase
Template:ABSTRACT PUBMED 12820976
Function
[SMUG1_XENLA] Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. No enzymatic activity towards G/T mismatches.
About this Structure
1oe5 is a 4 chain structure with sequence from Xenopus laevis. Full crystallographic information is available from OCA.
See Also
Reference
- Wibley JE, Waters TR, Haushalter K, Verdine GL, Pearl LH. Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1. Mol Cell. 2003 Jun;11(6):1647-59. PMID:12820976
