1uzg

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[[Category: virus/viral protein]]
[[Category: virus/viral protein]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:21:09 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 16:16:28 2007''

Revision as of 14:11, 30 October 2007

Image:1uzg.gif

1uzg, resolution 3.50Å

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CRYSTAL STRUCTURE OF THE DENGUE TYPE 3 VIRUS ENVELOPE PROTEIN

Overview

Dengue virus is an emerging global health threat. The major envelope, glycoprotein, E, mediates viral attachment and entry by membrane fusion., Antibodies that bind but fail to neutralize noncognate serotypes enhance, infection. We have determined the crystal structure of a soluble fragment, of the envelope glycoprotein E from dengue virus type 3. The structure, closely resembles those of E proteins from dengue type 2 and tick-borne, encephalitis viruses. Serotype-specific neutralization escape mutants in, dengue virus E proteins are all located on a surface of domain III, which, has been implicated in receptor binding. While antibodies against epitopes, in domain I are nonneutralizing in dengue virus, there are neutralizing, antibodies that recognize serotype-conserved epitopes in domain ... [(full description)]

About this Structure

1UZG is a [Single protein] structure of sequence from [Dengue virus type 1] with FUL, BMA and NAG as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein., Modis Y, Ogata S, Clements D, Harrison SC, J Virol. 2005 Jan;79(2):1223-31. PMID:15613349

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