4i6p

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'''Unreleased structure'''
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{{STRUCTURE_4i6p| PDB=4i6p | SCENE= }}
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===Crystal structure of Par3-NTD domain===
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{{ABSTRACT_PUBMED_23643951}}
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The entry 4i6p is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PARD3_RAT PARD3_RAT]] Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Targets the phosphatase PTEN to cell junctions.<ref>PMID:18082612</ref> <ref>PMID:18550519</ref>
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Authors: Wang, W., Gao, F., Gong, W., Sun, F., Feng, W.
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==About this Structure==
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[[4i6p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I6P OCA].
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Description: Crystal structure of Par3-NTD domain
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==Reference==
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<ref group="xtra">PMID:023643951</ref><references group="xtra"/><references/>
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[[Category: Rattus norvegicus]]
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[[Category: Feng, W.]]
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[[Category: Gao, F.]]
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[[Category: Gong, W.]]
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[[Category: Sun, F.]]
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[[Category: Wang, W.]]
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[[Category: Cell polarity protein]]
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[[Category: Duf3534]]
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[[Category: Pb1 like motif]]
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[[Category: Signaling protein]]

Revision as of 04:54, 18 July 2013

Template:STRUCTURE 4i6p

Contents

Crystal structure of Par3-NTD domain

Template:ABSTRACT PUBMED 23643951

Function

[PARD3_RAT] Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Targets the phosphatase PTEN to cell junctions.[1] [2]

About this Structure

4i6p is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Zhang Y, Wang W, Chen J, Zhang K, Gao F, Gao B, Zhang S, Dong M, Besenbacher F, Gong W, Zhang M, Sun F, Feng W. Structural insights into the intrinsic self-assembly of par-3 N-terminal domain. Structure. 2013 Jun 4;21(6):997-1006. doi: 10.1016/j.str.2013.04.004. Epub 2013, May 2. PMID:23643951 doi:10.1016/j.str.2013.04.004
  1. ↑ Wu H, Feng W, Chen J, Chan LN, Huang S, Zhang M. PDZ domains of Par-3 as potential phosphoinositide signaling integrators. Mol Cell. 2007 Dec 14;28(5):886-98. PMID:18082612 doi:10.1016/j.molcel.2007.10.028
  2. ↑ Feng W, Wu H, Chan LN, Zhang M. Par-3-mediated junctional localization of the lipid phosphatase PTEN is required for cell polarity establishment. J Biol Chem. 2008 Aug 22;283(34):23440-9. doi: 10.1074/jbc.M802482200. Epub 2008 , Jun 10. PMID:18550519 doi:10.1074/jbc.M802482200

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